KIN Antibody

Datasheet

Code	CSB-PA012351GA01HU
Size	$600
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Target Background

Product Details

Uniprot No.

O60870

Target Names

KIN

Alternative Names

KIN antibody; BTCD antibody; KIN17DNA/RNA-binding protein KIN17 antibody; Binding to curved DNA antibody; KIN antibody; antigenic determinant of recA protein homolog antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human KIN

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C-terminal domain to RNA in vitro.

Gene References into Functions

Findings demonstrate that kin17 is closely related to the cell proliferation and invasion of cervical cancer. PMID: 28346239
overexpression of KIN rendered colorectal cancer cells enriching cancer stem cell (CSC) markers and CSC phenotype, and silencing KIN reduced CSC markers and CSC phenotype. PMID: 24755081
Trimethylated at Lys-135 by METTL22 PMID: 23349634
up-regulation of kin17 is strongly associated with cellular proliferation, DNA replication, DNA damage response and breast cancer development PMID: 21980430
ionizing radiation triggers chromatin complex formation in human cells PMID: 11880372
The overexpression of human kin17 protein in vivo and the introduction of increased amounts of human kin17 protein in an in vitro assay reduced T-antigen-dependent DNA replication. PMID: 12359749
results indicate the presence of functional XPA and XPC proteins is essential for the up-regulation of the KIN17 gene after UVC irradiation; also show that the integrity of global genome repair is required to trigger KIN17 gene expression PMID: 12525703
KIN17 protein may be a component of the DNA replication machinery that participates in the cellular response to unrepaired DSBs, and an impaired KIN17 pathway leads to an increased sensitivity to ionizing radiation. PMID: 12751957
A chromatin-associated protein conserved during evolution and overproduced in certain human tumor cell lines, which is involved in DNA replication. PMID: 12754299
Kin17 protein strongly associates in vivo with DNA fragments containing replication origins in both human HeLa and monkey CV-1 cells. PMID: 15831485
C-terminal domain of human KIN17 has a basic pI, heavy-atom derivatives were obtained by soaking crystals with negatively charged ions such as tungstate & iodine. Replacement of LiCl by KI in cryosolution allowed determination of phases from iodide ions. PMID: 16511313
Analysis of KIN17 structure complexed with tungstate shows structural variability within the domain PMID: 17045609
Thus, human KIN17 region 51-160 might rather be involved in protein-protein interaction through its conserved surface centered on the 3(10)-helix. PMID: 18029424

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

KIN17 family

Tissue Specificity

Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte cells in vitro (at

Database Links

HGNC: 6327

OMIM: 601720

KEGG: hsa:22944

STRING: 9606.ENSP00000368881

UniGene: Hs.397918

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