KIR3DS1 Antibody

1. interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. PMID: 30031767
2. The combination of KIR3DS1 with homozygosity for HLA-Bw4 alleles (the putative ligand for KIR3DS1) was significantly less frequent in the HIV-1 infected group than in the control group PMID: 29664957
3. Furthermore, the KIR3DS1 + HLA-Bw4, KIR3DS1 + HLA-Bw4 (Iso80) , and KIR3DS1 + HLA-A Bw4 genotypes were significantly more common in recovered individuals than both healthy control and patient groups. PMID: 29032460
4. KIR3DS1*01301, 3DL1*00401, and 3DL1*00402 showed susceptibility and elevated mRNA expression and is associated with antibody mediated acute rejection and chronic rejection. PMID: 28942035
5. Study assessed which of the TB01 encoded KIR gene products contributed to Natural Killer cell responsiveness; of the TB01 KIR gene products examined, only KIR3DS1 conferred responsiveness to HLA-null stimulation, demonstrating its ligation can activate ex vivo Natural Killer cells. PMID: 28938026
6. genetic polymorphism is not related to acute myeloid leukemia in Chinese population PMID: 25636577
7. The data from this study contribute novel insight into how KIR3DS1-specific polymorphisms in the extracellular region impact KIR3DL1 surface expression, ligand binding, and inhibitory function. PMID: 26109640
8. Data suggest that low level of activating KIR3DS1 and its combination with HLA-B Bw4Ile80 ligand might have an influence on the susceptibility to tuberculosis (TB) in Lur population of Iran. PMID: 22426166
9. KIR3DS1, in addition to HLA-B27, may play an important independent role in the pathogenesis of ankylosing spondylitis in the Chinese population. PMID: 22744805
10. Results show that the KIR3DS1 genotype has a positive effect on HCV viral clearance during the first weeks of Peg-IFN/RBV treatment in HCV/HCV co-infected patients bearing genotype 1, and higher RVR and SVR rates. PMID: 23613999
11. results suggest that the sole presence of KIR3DS1 could have a protective role in HIV-1 infection in highly exposed and persistently seronegative individuals PMID: 23789883
12. There is evidence of the association of activating KIR genotypes with an increased risk for autoimmune disease PMID: 21779711
13. Our results that KIR2DL5 and KIR3DS1 may have a predisposing role in multiple sclerosis PMID: 21665278
14. These data provide the first evidence for the direct binding of KIR3DS1(+) cells to HLA-Bw4 and highlight the key role for position 138 in determining ligand specificity of KIR3DS1 PMID: 21804024
15. The most significant difference in PFS observed in multiple myeloma patients after autologous stem cell transplantation was with those with GR KIR3DS1(+) in whom HLA-Bw4, the ligand for the corresponding inhibitory receptor KIR3DL1, was missing PMID: 20562327
16. The increased frequency of the KIR3DS1*013 allele in patients with amnkylosing spondylitis is clearly independent of the presence of the HLA-Bw4I80 epitope. PMID: 20131260
17. Compared with KIR3DS1(-) donors, donor KIR3DS1 was associated with lower-grade II-IV acute graft-versus-host disease. PMID: 20124216
18. Carriage of activating 3ds1 was increased in patients with herpes virus RDs. PMID: 17592337
19. Sequencing analysis identified a variant with a complex deletion/substitution mutation in exon 4 (which encodes the D1 extracellular domain), resulting in a premature stop codon and might affect its expression and activating capacity PMID: 17687550
20. Variation at the KIR locus influences the effectiveness of NK cell activity in the containment of viral replication. PMID: 18025129
21. We observed that possessing KIR3DS1 was associated with higher NK cell effector functions in early HIV-1 disease, despite the absence of HLA Bw4Ile80, a putative ligand of KIR3DS1. PMID: 18305035
22. KIR3DS1 expression on NK cells can be induced after exposure to stimulator cells PMID: 19454667

Show More

Hide All

HGNC: 6340

OMIM: 604946

KEGG: hsa:3813

STRING: 9606.ENSP00000375608

UniGene: Hs.645228