KLF11 Antibody

1. Profibrotic gene expression was activated in a primary human peritoneal cell line in response to KLF11 short hairpin RNA and medroxyprogesterone acetate but not estradiol. PMID: 28938437
2. In endometrial-stromal fibroblasts, KLF11 recruited SIN3A/HDAC (histone deacetylase), resulting in COL1A1-promoter deacetylation and repression PMID: 26935598
3. Results suggest a role for KLF11 in upregulating MAO-A in depressive disorder and chronic social stress, suggesting that inhibition of the pathways regulated by this transcription factor may aid in the therapeutics of neuropsychiatric illnesses PMID: 25502632
4. The data suggest a relationship between promoter DNA methylation and KLF11 gene expression in ovarian cancer tumorigenesis. PMID: 25931269
5. identified an evolutionarily conserved metabolic regulator, Kruppel-like factor 11 (KLF11), as a novel browning transcription factor in human adipocytes that is required for rosiglitazone-induced browning. PMID: 25504365
6. KLF11 repressed most endometrial CYP enzymes PMID: 25076120
7. Levels of KLF11 are significantly increased in the postmortem prefrontal cortex of subjects with alcohol dependence compared to controls. PMID: 23915421
8. KLF11 regulates distinct gene networks. PMID: 24885560
9. KLF111 represses glycodelin-A levels and influences its role in the ovarian endometrium. PMID: 24060634
10. KLF11 is a critical transcription factor in the function of mesenchymal cells and, specifically, as a negative regulator of collagen secretion. PMID: 24069400
11. Data identify a novel pathogenic role for KLF11 in preventing de novo disease-associated fibrosis in endometriosis. PMID: 23555910
12. The A347S mutation disrupted KLF11-mediated increases in basal insulin levels and promoter activity and blunted glucose-stimulated insulin secretion. PMID: 23589285
13. Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis. PMID: 22930747
14. KLF11 has a role in fine-tuning insulin transcription in certain cellular situations rather than representing a major transcriptional activator or repressor of the insulin gene. PMID: 22801105
15. Kruppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-kappaB signaling pathway. PMID: 23042817
16. KLF11 is an MAO A regulator and is produced in response to neuronal stress, which transcriptionally activates MAO A. PMID: 22628545
17. Here we report the characterization of two antagonistic, chromatin-mediated mechanisms by which KLF11 regulated the transcription of the dopamine D2 receptor. PMID: 22375010
18. A PXVXL HP1-interacting domain identified at position 487-491 of KLF11 mediates the binding of HP1alpha and KLF11 in vitro and in cultured cells. PMID: 22318730
19. an important role for KLF11 in the regulation of INS transcription via the novel c.-331 KLF site. PMID: 21592955
20. epigenetic inactivation and subsequent transcriptional repression of the KLF11 gene is quite frequent in MDS. PMID: 20002157
21. Kruppel-like factor 11 has a role in the regulation of prostaglandin E2 biosynthesis PMID: 20154088
22. KLF11 is an integrator of progesterone receptor signaling and proliferation in uterine leiomyoma cells. PMID: 20124487
23. TIEG2 is an activator of Monoamine oxidase B gene expression. PMID: 15024015
24. novel mechanism in TGF-beta-regulated gene expression: KLF11 potentiates Smad-signaling activity in normal epithelial cells through termination of the negative feedback loop imposed by Smad7. PMID: 15300592
25. in the presence of cholesterol, KLF11 acts as a dominant repressor of the caveolin-1 gene PMID: 15531587
26. KLF11 plays a role in the regulation of pancreatic beta cell physiology, and its variants may contribute to the development of diabetes. PMID: 15774581
27. These results suggest a central role for KLF11 in TGFbeta-induced c-myc repression and antiproliferation. PMID: 17114344
28. KLF11 A347S and T220M mutations do not contribute to increased risk of diabetes in European-derived populations. PMID: 17130512
29. results may help to increase the understanding of Tieg3-mediated transcriptional control and to characterize this TGF-beta-induced Sp1/Klf-like transcription factor PMID: 17252542
30. TIEG2 decreases the levels of the anti-apoptotic protein Bcl-X(L) and inhibits transcription driven by the Bcl-X(L) promoter. PMID: 17308981
31. Kruppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells PMID: 17479246
32. KLF11 may interfere with glucose homeostasis in a Danish general population and that STAT3-mediated up-regulation of KLF11 transcription was impaired by the -1659G>C variant. PMID: 18505768
33. KLF11 is unlikely to play a major role in the etiology of T2 diabetes among this Native American population. PMID: 18593768
34. 19 polymorphisms, 6 of which are novel, were identified, but none of them showed association with type 2 diabetes. Functional analyses of these variants showed reduced effects on transcriptional activities of insulin, catalase1, & the Smad7 gene. PMID: 19122346
35. MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells. PMID: 19843526

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HGNC: 11811

OMIM: 603301

KEGG: hsa:8462

STRING: 9606.ENSP00000307023

UniGene: Hs.12229