Kng1 Antibody

^{Rare Species}

Datasheet

Code	CSB-PA012479LA01RA
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Rattus norvegicus (Rat) Kng1 Polyclonal antibody

Uniprot No.

P08934

Target Names

Kng1

Alternative Names

Kng1 antibody; Kng antibody; Kininogen-1 [Cleaved into: Kininogen-1 heavy chain; Bradykinin; Kininogen-1 light chain] antibody

Raised in

Rabbit

Species Reactivity

Rat

Immunogen

Recombinant Rat Kininogen-1 protein (2-110AA)

Immunogen Species

Rattus norvegicus (Rat)

Conjugate

Non-conjugated

The Kng1 Antibody (Product code: CSB-PA012479LA01RA) is Non-conjugated. For Kng1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA012479LB01RA	Kng1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA012479LC01RA	Kng1 Antibody, FITC conjugated
Biotin	CSB-PA012479LD01RA	Kng1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Gene References into Functions

High-molecular-weight kininogen and its peptide fragments modulate arterial thrombosis after arterial injury. PMID: 17293494

Subcellular Location

Secreted, extracellular space.

Tissue Specificity

Plasma.

Database Links

KEGG: rno:25087

STRING: 10116.ENSRNOP00000065146

UniGene: Rn.128333

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Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Complement and coagulation cascades

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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