L3MBTL2 Antibody, FITC conjugated

Code CSB-PA839279LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) L3MBTL2 Polyclonal antibody
Uniprot No.
Target Names
L3MBTL2
Alternative Names
3bt like 2 protein antibody; 3bt like protein antibody; DKFZP761I141 antibody; H-l(3)mbt-like protein 2 antibody; H-l(3)mbt-like protein antibody; Hl antibody; Hl(3)mbt like protein antibody; Hl(3)mbtl antibody; L antibody; l(3)mbt like 2 (Drosophila) antibody; l(3)mbt like 2 antibody; L(3)mbt-like 2 protein antibody; L(3)mbt-like protein 2 antibody; L3MBTL2 antibody; Lethal antibody; Lethal(3)malignant brain tumor-like 2 protein antibody; Lethal(3)malignant brain tumor-like protein 2 antibody; LMBL2_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Lethal(3)malignant brain tumor-like protein 2 protein (1-230AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.
Gene References into Functions
  1. L3MBTL2 polymorphism is associated with neuroticism. PMID: 27918536
  2. Our findings highlight a PcG/L3MBTL2 collaboration that attains repressive chromatin without entailing histone lysine methylation marks. PMID: 21596310
  3. High-resolution crystallographic analysis of the four MBT repeats of L3MBTL2 reveals its unique asymmetric rhomboid architecture, as well as binding mechanism, which preclude the interaction of the first three MBT repeats with methylated peptides. PMID: 19233876
  4. determination of the solution structure of the FCS zinc finger of L3MBTL2; structure consists of a beta-hairpin followed by an alpha-helix; structure is consistent with the proposal that FCS zinc fingers bind to regulatory RNAs PMID: 19241375
Subcellular Location
Nucleus.
Database Links

HGNC: 18594

OMIM: 611865

KEGG: hsa:83746

STRING: 9606.ENSP00000216237

UniGene: Hs.517641

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