LAMB3 Antibody

Code CSB-PA615717LA01HU
Size US$166
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  • IHC image of CSB-PA615717LA01HU diluted at 1:300 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA615717LA01HU diluted at 1:300 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LAMB3 Polyclonal antibody
Uniprot No.
Target Names
LAMB3
Alternative Names
BM600 125KDA antibody; Epiligrin subunit bata antibody; FLJ99565 antibody; Kalinin B1 chain antibody; Kalinin subunit beta antibody; LAM5 antibody; LAMB3 antibody; LAMB3_HUMAN antibody; Laminin B1k chain antibody; Laminin subunit beta-3 antibody; Laminin-5 subunit beta antibody; LAMNB1 antibody; Nicein subunit beta antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Laminin subunit beta-3 protein (256-397AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The LAMB3 Antibody (Product code: CSB-PA615717LA01HU) is Non-conjugated. For LAMB3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA615717LB01HU LAMB3 Antibody, HRP conjugated ELISA
FITC CSB-PA615717LC01HU LAMB3 Antibody, FITC conjugated
Biotin CSB-PA615717LD01HU LAMB3 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Gene References into Functions
  1. From these results, it was shown that laminin-332 is an essential niche component for the proper differentiation of Interfollicular epidermal stem cells. PMID: 29555367
  2. the gentamicin-induced laminin beta3 led to the restoration of laminin 332 assembly, secretion, and deposition within the dermal/epidermal junction, as well as proper polarization of alpha6beta4 integrin in basal keratinocytes PMID: 29946029
  3. Results show three specific LAMB3 mutations: c.823-1G>A, c.957ins77 and c.3228+1G>A are carried by 91% of all LAMB3 alleles and that at least one of these three mutations will be carried in junctional epidermolysis bullosa individuals in this Chilean population. PMID: 27480391
  4. expression in preoperative biopsy material predictive of perineural invasion in patients with oral squamous cell carcinoma PMID: 27863864
  5. The authors have identified a mutation in LAM3 causing lethal epidermolysis bullosa in a Balkan, Hungarian, population. Investigations into the genetic background of its unique carrier group, suggests that the estimated age of the mutation corresponds to the period of Roma migration in the Balkans. PMID: 27062385
  6. the tyrosine kinase FAK and the laminin subunit LAMB3 as functional targets of miR-1298. Silencing of FAK or LAMB3 recapitulated the synthetic lethal effects of miR-1298 expression in KRAS-driven cancer cells. PMID: 27698189
  7. The expression of fascin-1 and lanminin-5 and the serum levels of fascin-1 and laminin-5 were related to the relapse of patients with non-small cell lung cancer. PMID: 28653739
  8. Whole-Exome Sequencing Suggests LAMB3 as a Susceptibility Gene for Morbid Obesity PMID: 27431458
  9. Case Reports: Junctional epidermolysis bullosa with LAMB3 splice-site mutations. PMID: 25708563
  10. LNbeta3 expression may play a key role in the progression and prognosis of pancreatic ductal adenocarcinoma. PMID: 25032755
  11. Screening of ENAM and LAMB3 genes was performed by direct sequencing of genomic DNA from blood samples. PMID: 25769099
  12. Case Report: linear IgA/IgG bullous dermatosis with anti-laminin-332 autoantibodies. PMID: 24978847
  13. An algorithm combining CLDN10, HMGA2, and LAMB3 transcripts was able to discriminate tumors from BTL samples (94% sensitivity and 96% specificity in validation set). PMID: 25867809
  14. Novel LAMB3 mutations cause non-syndromic amelogenesis imperfecta with variable expressivity. PMID: 24494736
  15. we report a case of Herlitz junctional epidermolysis bullosa with a novel heterozygous mutation in LAMB3,c.1597G>A (p.Ala533Thr). PMID: 23278291
  16. However, to our knowledge, this is the first report of dominant AI due to a LAMB3 mutation in the absence of JEB. PMID: 23632796
  17. data further enhance the mutation spectrum of the LAMB3 and the COL7A1 genes, and also underscore the crucial roles of these genes in pathogenesis of epidermolysis bullosa PMID: 23769655
  18. an 8-bp deletion (c.3446_3453del GACTGGAG) shifting the reading frame (p.Gly 1149Glufs*8) and a single nucleotide substitution (c.C3431A) generating an in-frame translation termination codon (p.Ser1144*)associated with amelogenesis imperfecta PMID: 23958762
  19. Results identify the point during neoplastic progression in epithelia when the tumor suppressor p16 and laminin 5 are expressed and suggest that normal epithelia may use the same mechanism to generate non-dividing, motile cells for wound repair. PMID: 12875969
  20. Laminin-5 is a useful biomarker in the evaluation of invasiveness in cervical adenocarcinoma. PMID: 22898004
  21. These results suggest that epigenetic activation of LAMB3 and LAMC2 may play an important role in gastric carcinogenesis. PMID: 21345334
  22. The LAMB3 rs2566 variant CT/TT genotypes were associated with a significantly increased risk of cervical cancer, compared with the wild type CC genotype. PMID: 20163849
  23. Gene LAMB3 detected compound heterozygosity for the nonsense mutation R635X and a novel 2 bp deletion (1587delAG) resulting in a downstream premature termination codon. PMID: 11689492
  24. Deletion analysis of laminin-beta3 indicated that the region comprising aa 726 to 875 of laminin-beta3 interacts with rotavirus enterotoxin NSP4. PMID: 15331737
  25. In squamous cell carcinoma of the tongue and colorectal carcinoma, laminin 5 beta3 chain is important in the invasiveness of cancer cells. PMID: 15363037
  26. homozygous frameshift mutation in LAMB3 was associated to illegitimate splicing leading to non-H junctional epidermolysis bullosa PMID: 15373767
  27. DNA analysis revealed a compound heterozygote for mutations 2379delG and Q995X in the LAMB3 gene in Herlitz junctional epidermolysis bullosa PMID: 16147969
  28. Multiple second-site mutations, all correcting the germline mutation LAMB3 (628G-->A;Glu210Lys), are present in 2 unrelated non-Herlitz junctional epidermolysis bullosa patients with revertant mosaicism. PMID: 17476356
  29. degradation [by Candida species] can exert functional disturbances on basement membrane integrity, possibly aiding Candida cell invasion into tissues PMID: 18284540
  30. The expression of LAMB3 mrna was higher in malignant tissue and correlated with the depth of invasion and venous invasion in ESCC. PMID: 18331784
  31. c.1945dupG mutation in Herlitz junctional epidermolysis bullosa PMID: 18387282
  32. Ln-332 gamma2 may be a therapeutic target against metastatic colon cancer because a lowered beta3:gamma2 ratio would reduce expression of heterotrimeric Ln-332 and increase monomeric gamma2 secretion. PMID: 19383890
  33. Histopathology of anti-laminin 5 mucous membrane pemphigoid is characterized by subepidermal blistering and a sparse to moderate superficial lymphohistiocytic infiltrate with neutrophils and/or eosinophils PMID: 19700013
  34. Results suggest that laminin (LN)gamma2 and LNbeta3, in conjunction with MMP7, play a key role in the progression of biliary tract cancer. PMID: 19701966

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Involvement in disease
Epidermolysis bullosa, junctional, Herlitz type (H-JEB); Generalized atrophic benign epidermolysis bullosa (GABEB); Amelogenesis imperfecta 1A (AI1A)
Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane.
Tissue Specificity
Found in the basement membranes (major component).
Database Links

HGNC: 6490

OMIM: 104530

KEGG: hsa:3914

STRING: 9606.ENSP00000348384

UniGene: Hs.497636

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