Recombinant Human Laminin subunit beta-3 (LAMB3), partial

1. From these results, it was shown that laminin-332 is an essential niche component for the proper differentiation of Interfollicular epidermal stem cells. PMID: 29555367
2. the gentamicin-induced laminin beta3 led to the restoration of laminin 332 assembly, secretion, and deposition within the dermal/epidermal junction, as well as proper polarization of alpha6beta4 integrin in basal keratinocytes PMID: 29946029
3. Results show three specific LAMB3 mutations: c.823-1G>A, c.957ins77 and c.3228+1G>A are carried by 91% of all LAMB3 alleles and that at least one of these three mutations will be carried in junctional epidermolysis bullosa individuals in this Chilean population. PMID: 27480391
4. expression in preoperative biopsy material predictive of perineural invasion in patients with oral squamous cell carcinoma PMID: 27863864
5. The authors have identified a mutation in LAM3 causing lethal epidermolysis bullosa in a Balkan, Hungarian, population. Investigations into the genetic background of its unique carrier group, suggests that the estimated age of the mutation corresponds to the period of Roma migration in the Balkans. PMID: 27062385
6. the tyrosine kinase FAK and the laminin subunit LAMB3 as functional targets of miR-1298. Silencing of FAK or LAMB3 recapitulated the synthetic lethal effects of miR-1298 expression in KRAS-driven cancer cells. PMID: 27698189
7. The expression of fascin-1 and lanminin-5 and the serum levels of fascin-1 and laminin-5 were related to the relapse of patients with non-small cell lung cancer. PMID: 28653739
8. Whole-Exome Sequencing Suggests LAMB3 as a Susceptibility Gene for Morbid Obesity PMID: 27431458
9. Case Reports: Junctional epidermolysis bullosa with LAMB3 splice-site mutations. PMID: 25708563
10. LNbeta3 expression may play a key role in the progression and prognosis of pancreatic ductal adenocarcinoma. PMID: 25032755
11. Screening of ENAM and LAMB3 genes was performed by direct sequencing of genomic DNA from blood samples. PMID: 25769099
12. Case Report: linear IgA/IgG bullous dermatosis with anti-laminin-332 autoantibodies. PMID: 24978847
13. An algorithm combining CLDN10, HMGA2, and LAMB3 transcripts was able to discriminate tumors from BTL samples (94% sensitivity and 96% specificity in validation set). PMID: 25867809
14. Novel LAMB3 mutations cause non-syndromic amelogenesis imperfecta with variable expressivity. PMID: 24494736
15. we report a case of Herlitz junctional epidermolysis bullosa with a novel heterozygous mutation in LAMB3,c.1597G>A (p.Ala533Thr). PMID: 23278291
16. However, to our knowledge, this is the first report of dominant AI due to a LAMB3 mutation in the absence of JEB. PMID: 23632796
17. data further enhance the mutation spectrum of the LAMB3 and the COL7A1 genes, and also underscore the crucial roles of these genes in pathogenesis of epidermolysis bullosa PMID: 23769655
18. an 8-bp deletion (c.3446_3453del GACTGGAG) shifting the reading frame (p.Gly 1149Glufs*8) and a single nucleotide substitution (c.C3431A) generating an in-frame translation termination codon (p.Ser1144*)associated with amelogenesis imperfecta PMID: 23958762
19. Results identify the point during neoplastic progression in epithelia when the tumor suppressor p16 and laminin 5 are expressed and suggest that normal epithelia may use the same mechanism to generate non-dividing, motile cells for wound repair. PMID: 12875969
20. Laminin-5 is a useful biomarker in the evaluation of invasiveness in cervical adenocarcinoma. PMID: 22898004
21. These results suggest that epigenetic activation of LAMB3 and LAMC2 may play an important role in gastric carcinogenesis. PMID: 21345334
22. The LAMB3 rs2566 variant CT/TT genotypes were associated with a significantly increased risk of cervical cancer, compared with the wild type CC genotype. PMID: 20163849
23. Gene LAMB3 detected compound heterozygosity for the nonsense mutation R635X and a novel 2 bp deletion (1587delAG) resulting in a downstream premature termination codon. PMID: 11689492
24. Deletion analysis of laminin-beta3 indicated that the region comprising aa 726 to 875 of laminin-beta3 interacts with rotavirus enterotoxin NSP4. PMID: 15331737
25. In squamous cell carcinoma of the tongue and colorectal carcinoma, laminin 5 beta3 chain is important in the invasiveness of cancer cells. PMID: 15363037
26. homozygous frameshift mutation in LAMB3 was associated to illegitimate splicing leading to non-H junctional epidermolysis bullosa PMID: 15373767
27. DNA analysis revealed a compound heterozygote for mutations 2379delG and Q995X in the LAMB3 gene in Herlitz junctional epidermolysis bullosa PMID: 16147969
28. Multiple second-site mutations, all correcting the germline mutation LAMB3 (628G-->A;Glu210Lys), are present in 2 unrelated non-Herlitz junctional epidermolysis bullosa patients with revertant mosaicism. PMID: 17476356
29. degradation [by Candida species] can exert functional disturbances on basement membrane integrity, possibly aiding Candida cell invasion into tissues PMID: 18284540
30. The expression of LAMB3 mrna was higher in malignant tissue and correlated with the depth of invasion and venous invasion in ESCC. PMID: 18331784
31. c.1945dupG mutation in Herlitz junctional epidermolysis bullosa PMID: 18387282
32. Ln-332 gamma2 may be a therapeutic target against metastatic colon cancer because a lowered beta3:gamma2 ratio would reduce expression of heterotrimeric Ln-332 and increase monomeric gamma2 secretion. PMID: 19383890
33. Histopathology of anti-laminin 5 mucous membrane pemphigoid is characterized by subepidermal blistering and a sparse to moderate superficial lymphohistiocytic infiltrate with neutrophils and/or eosinophils PMID: 19700013
34. Results suggest that laminin (LN)gamma2 and LNbeta3, in conjunction with MMP7, play a key role in the progression of biliary tract cancer. PMID: 19701966

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HGNC: 6490

OMIM: 104530

KEGG: hsa:3914

STRING: 9606.ENSP00000348384

UniGene: Hs.497636