LCE3C Antibody, FITC conjugated

Code CSB-PA725885LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LCE3C Polyclonal antibody
Uniprot No.
Target Names
LCE3C
Alternative Names
LCE3C antibody; LEP15 antibody; SPRL3ALate cornified envelope protein 3C antibody; Late envelope protein 15 antibody; Small proline-rich-like epidermal differentiation complex protein 3A antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Late cornified envelope protein 3C protein (1-94AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.
Gene References into Functions
  1. analysis of disease variants at the LCE3 cluster among the psoriasis patients in India PMID: 27048876
  2. Our data suggest that The LCE deletion, previously identified in patients with psoriasis, is not of a major importance in the development of PsA in Tunisian patients PMID: 24566688
  3. No evidence of association was seen between the LCE3C_LCE3B-del and psoriasis in 34 patients from 7 multiplex Tunisian families. No epistasic effect was found between the deletion and PSORS1 locus. PMID: 24485035
  4. Our meta-analysis demonstrates a significant association between psoriasis and the LCE3C_LCE3B-del polymorphism in Europeans and Asians, but no association with psoriatic arthritis. PMID: 23631431
  5. The LCE3C_LCE3B-del might play a role in familial psoriasis in the Tunisian population. PMID: 22926764
  6. Paediatric-onset psoriasis is associated with .......... LCE3C_LCE3B deletion PMID: 22512642
  7. LCE3C_LCE3B-del is a common risk factor for (auto)immune diseases PMID: 22384135
  8. results suggest that the Koebner phenomenon in psoriasis is unlikely to be dependent on the LCE3B/C genotype PMID: 22048733
  9. The findings indicate that the LCE3C_LCE3B-del is an important risk factor in the pathogenesis of psoriasis and that the LCE3C_LCE3B-del does not show an epistatic effect with the HLA-Cw6 allele on susceptibility to psoriasis in the northern Chinese. PMID: 21711330
  10. A deletion of LCE3B and LCE3C genes may promote the development of allergic contact dermatitis PMID: 21995181
  11. This study provides evidence for an association between LCE3C_LCE3B-del and RA in non-Caucasian populations, and SNPs rs4112788 and rs4085613 tagging LCE3C_LCE3B-del were novel susceptibility factors for SLE. PMID: 21628307
  12. Our study confirms an association between the deletion of LCE3C and LCE3B and psoriasis in a Chinese population. PMID: 21509048
  13. LCE3C_LCE3B deletion is a susceptibility factor for Psoriatic arthritis, confirming the existence of a shared risk factor involving the epidermal skin barrier in autoimmune disorders. PMID: 21400479
  14. LCE3B/C deletion may have a role in psoriasis PMID: 21435436
  15. the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European, Chinese and Mongolian populations. PMID: 21107349
  16. Meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20624365
  17. no genetic association betwwen LCE3B and LCE3c deletions and atopic dermatitis PMID: 20376060
  18. Observational study of gene-disease association. (HuGE Navigator) PMID: 20376060
  19. we have verified a pleiotropic effect of a common genetic risk factor (LCE3C_LCE3B-del) for autoimmune diseases that is involved in both psoriasis and rheumatoid arthritis PMID: 20213803
  20. work suggested that homozygosity for a common LCE3C_LCE3B deletion contributes to the risk of developing chronic plaque type Ps without psoriatic arthritis PMID: 20331852
  21. study confirms the recently published finding that the deletion of the two LCE genes is a susceptibility factor for psoriasis vulgaris with dosage effect PMID: 20016497
  22. Observational study of gene-disease association. (HuGE Navigator) PMID: 20213803
  23. Observational study of gene-disease association. (HuGE Navigator) PMID: 20331852
  24. LCE3C_LCE3B-del shows epistatic effects with the HLA-Cw6 allele on the development of psoriasis. PMID: 19169253
  25. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20016497
  26. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 19169253
  27. paper describing nomenclature changes and expression in range of tissues and in response to UV PMID: 15854049

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Protein Families
LCE family
Tissue Specificity
Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.
Database Links

HGNC: 16612

OMIM: 612615

KEGG: hsa:353144

STRING: 9606.ENSP00000334644

UniGene: Hs.490211

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