LCE3C antibody; LEP15 antibody; SPRL3ALate cornified envelope protein 3C antibody; Late envelope protein 15 antibody; Small proline-rich-like epidermal differentiation complex protein 3A antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Late cornified envelope protein 3C protein (1-94AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.
Gene References into Functions
analysis of disease variants at the LCE3 cluster among the psoriasis patients in India PMID: 27048876
Our data suggest that The LCE deletion, previously identified in patients with psoriasis, is not of a major importance in the development of PsA in Tunisian patients PMID: 24566688
No evidence of association was seen between the LCE3C_LCE3B-del and psoriasis in 34 patients from 7 multiplex Tunisian families. No epistasic effect was found between the deletion and PSORS1 locus. PMID: 24485035
Our meta-analysis demonstrates a significant association between psoriasis and the LCE3C_LCE3B-del polymorphism in Europeans and Asians, but no association with psoriatic arthritis. PMID: 23631431
The LCE3C_LCE3B-del might play a role in familial psoriasis in the Tunisian population. PMID: 22926764
Paediatric-onset psoriasis is associated with .......... LCE3C_LCE3B deletion PMID: 22512642
LCE3C_LCE3B-del is a common risk factor for (auto)immune diseases PMID: 22384135
results suggest that the Koebner phenomenon in psoriasis is unlikely to be dependent on the LCE3B/C genotype PMID: 22048733
The findings indicate that the LCE3C_LCE3B-del is an important risk factor in the pathogenesis of psoriasis and that the LCE3C_LCE3B-del does not show an epistatic effect with the HLA-Cw6 allele on susceptibility to psoriasis in the northern Chinese. PMID: 21711330
A deletion of LCE3B and LCE3C genes may promote the development of allergic contact dermatitis PMID: 21995181
This study provides evidence for an association between LCE3C_LCE3B-del and RA in non-Caucasian populations, and SNPs rs4112788 and rs4085613 tagging LCE3C_LCE3B-del were novel susceptibility factors for SLE. PMID: 21628307
Our study confirms an association between the deletion of LCE3C and LCE3B and psoriasis in a Chinese population. PMID: 21509048
LCE3C_LCE3B deletion is a susceptibility factor for Psoriatic arthritis, confirming the existence of a shared risk factor involving the epidermal skin barrier in autoimmune disorders. PMID: 21400479
LCE3B/C deletion may have a role in psoriasis PMID: 21435436
the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European, Chinese and Mongolian populations. PMID: 21107349
Meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20624365
no genetic association betwwen LCE3B and LCE3c deletions and atopic dermatitis PMID: 20376060
Observational study of gene-disease association. (HuGE Navigator) PMID: 20376060
we have verified a pleiotropic effect of a common genetic risk factor (LCE3C_LCE3B-del) for autoimmune diseases that is involved in both psoriasis and rheumatoid arthritis PMID: 20213803
work suggested that homozygosity for a common LCE3C_LCE3B deletion contributes to the risk of developing chronic plaque type Ps without psoriatic arthritis PMID: 20331852
study confirms the recently published finding that the deletion of the two LCE genes is a susceptibility factor for psoriasis vulgaris with dosage effect PMID: 20016497
Observational study of gene-disease association. (HuGE Navigator) PMID: 20213803
Observational study of gene-disease association. (HuGE Navigator) PMID: 20331852
LCE3C_LCE3B-del shows epistatic effects with the HLA-Cw6 allele on the development of psoriasis. PMID: 19169253
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20016497
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 19169253
paper describing nomenclature changes and expression in range of tissues and in response to UV PMID: 15854049
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Protein Families
LCE family
Tissue Specificity
Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.