LDOC1 Antibody

Code CSB-PA066576
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA066576(LDOC1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
LDOC1
Alternative Names
BCUR1 antibody; Breast cancer up regulated 1 antibody; Breast cancer upregulated 1 antibody; Gm366 antibody; Ldoc1 antibody; LDOC1_HUMAN antibody; Leucine zipper down regulated in cancer 1 antibody; Leucine zipper protein down regulated in cancer cells antibody; Leucine zipper protein down regulated in cancer cells antibody; Leucine zipper protein down-regulated in cancer cells antibody; Mar7 antibody; Mart7 antibody; Protein LDOC1 antibody; RGD1565644 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Fusion protein of Human LDOC1
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May have an important role in the development and/or progression of some cancers.
Gene References into Functions
  1. that epigenetic silencing of LDOC1 in high-risk Group A ependymoma regulates tumor biology and drives inflammatory immune phenotype PMID: 28510691
  2. GNL3L-LDOC1 interplay regulates cell proliferation through the modulation of NF-kappaB pathway during tumorigenesis. PMID: 27764577
  3. These finding of this study suggested that the hypothesize that LDOC1 gene upregulation may play a role in the spermatogenesis derangement observed in patients with Klinefelter Syndrome. PMID: 27076087
  4. data show that LDOC1 is a tumor suppressor in osteosarcoma, and that it regulates metastasis of osteosarcoma cells. Furthermore, LDOC1 might be a valuable prognostic marker in osteosarcomas. PMID: 28240050
  5. Cigarette smoke-induced promoter methylation may contribute to LDOC1 downregulation, thereby conferring oncogenic features to oral cells. PMID: 26317789
  6. LDOC1 inhibits proliferation and promotes apoptosis by repressing NF-kappaB activation in papillary thyroid carcinoma PMID: 26637328
  7. It has potential roles in apoptosis of well differentiated carcinoma without metastases and in neurodegeneration of Alzheimer's disease. PMID: 23775301
  8. Silencing of LDOC1 is a frequent event in cervical cancer and may be of interest as a molecular marker in cervical cancer. PMID: 24125169
  9. Silencing of BEX1 and LDOC1 by promoter hypermethylation might represent a critical event in the molecular pathogenesis of oral squamous cell carcinoma (OSCC) and the male predominance of OSCC occurrence. PMID: 23362108
  10. Letter/Case Report: LDOC1/PARP1 are down-regulated in melanoma with repeated in-transit metastases. PMID: 21986234
  11. The aim of this study was to evaluate the possible differential expression of LDOC1 mRNA in leucocytes of peripheral blood of Down's syndrome subjects. compared with the normal population. PMID: 22546831
  12. Over expression of LDOC1 may explain the clinical manifestation found in patients with cryptochidism and Digeorge anomaly. PMID: 21547351
  13. LDOC1 is dramatically down-regulated in mutated chronic lymphocytic leukemia cases compared with unmutated cases, and have identified a new splice variant, LDOC1S PMID: 21310924
  14. These observations suggest that LDOC1 is a novel regulator of NF-kappaB that can affect the PMA or TNF-alpha-mediated pathway to apoptosis through inhibition of NF-kappaB activation in BxPC3 pancreatic cancer cells. PMID: 12712434
  15. MZF-1 was revealed to interact with LDOC1 and enhance the activity of LDOC1 for inducing apoptosis PMID: 15670815

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Subcellular Location
Nucleus.
Protein Families
LDOC1 family
Tissue Specificity
Ubiquitously expressed with high levels in brain ant thyroid and low expression in placenta, liver and leukocytes. Expressed as well in six of the seven human breast cancer cell lines examined.
Database Links

HGNC: 6548

OMIM: 300402

KEGG: hsa:23641

STRING: 9606.ENSP00000359557

UniGene: Hs.45231

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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