LETMD1 Antibody

1. Data show that the activation of STAT3 protein upregulated human cervical cancer oncogene (HCCR) expression in gastric cancer cells. PMID: 27052330
2. Demonstrate that HBx-HCCR-E-cadherin regulation pathway might play an important role in HBV-induced hepatocarcinogenesis. PMID: 26470691
3. These findings suggest that HCCR gene is over-expressed in acute leukemia patients and may be a useful biomarker for monitoring minimal residual disease. PMID: 25034723
4. HCCR2 gene plays an important role in the tumorigenesis of leukemia. PMID: 24126909
5. HCCRBP-3 induces tumorigenesis through direct interaction with HCCR-1 in human cancers. PMID: 22851403
6. The data demonstrate that HCCR-1 may be used as a novel predictor for the prognosis of the patients with esophageal squamous cell carcinoma. PMID: 22511601
7. HCCR-1 might play a role in the breast tumourigenesis while the overexpression of HCCR-1 induces the obesity probably by inhibiting the cholesterol-lowering effect of ApoE PMID: 20196787
8. The overexpression of HCCR-2 could enhance the division and proliferation of SMMC 7721 cells. PMID: 21138632
9. induces neoplastic cell transformation and epithelial-mesenchymal transdifferentiation PMID: 20591135
10. Treatment of PANC-1 cells with epidermal growth factor increased HCCR-1 protein level via PI3K/Akt/mTOR signaling. PMID: 20423485
11. Human, similar to bacterial ribosomal protein L14 and yeast L22, gene L14.22 (clone 507E08), over-expressed in gliomas. PMID: 12061725
12. HCCR-2 probably represents a new oncogene that is related to tumorigenesis, functioning as a negative regulator of the p53 tumor suppressor PMID: 12879013
13. HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor. PMID: 14691448
14. HCCR oncoprotein has a role in development of human breast cancer PMID: 16278390
15. These results suggest that the HCCR-1 oncogene expression was regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway. PMID: 16949218
16. These experiments show the biological features of HCCR-1 in the cell, and suggest that uncontrolled expression of HCCR-1 may cause mitochondrial dysfunction. PMID: 18045496
17. Data indicate that the level of HCCR-1 in breast cancer tissues is correlated with the HER2 overexpression, p53 mutation, and ER/PR status, and determination of HCCR-1 levels as options for HER2 testing is promising although it needs further evaluation. PMID: 19208263
18. TCF and beta-catenin binding plays important roles in HCCR-1 oncogene expression. PMID: 19435525

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HGNC: 24241

KEGG: hsa:25875

STRING: 9606.ENSP00000262055

UniGene: Hs.655272