Recombinant Human LETM1 domain-containing protein 1 (LETMD1), partial

Code CSB-YP757554HU
MSDS
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Source Yeast
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Code CSB-EP757554HU
MSDS
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Source E.coli
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Code CSB-EP757554HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP757554HU
MSDS
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Source Baculovirus
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Code CSB-MP757554HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
LETMD1
Uniprot No.
Alternative Names
LETMD1LETM1 domain-containing protein 1; Cervical cancer 1 proto-oncogene protein p40; Cervical cancer proto-oncogene 2 protein; HCCR-1; HCRR-2
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.
Gene References into Functions
  1. Data show that the activation of STAT3 protein upregulated human cervical cancer oncogene (HCCR) expression in gastric cancer cells. PMID: 27052330
  2. Demonstrate that HBx-HCCR-E-cadherin regulation pathway might play an important role in HBV-induced hepatocarcinogenesis. PMID: 26470691
  3. These findings suggest that HCCR gene is over-expressed in acute leukemia patients and may be a useful biomarker for monitoring minimal residual disease. PMID: 25034723
  4. HCCR2 gene plays an important role in the tumorigenesis of leukemia. PMID: 24126909
  5. HCCRBP-3 induces tumorigenesis through direct interaction with HCCR-1 in human cancers. PMID: 22851403
  6. The data demonstrate that HCCR-1 may be used as a novel predictor for the prognosis of the patients with esophageal squamous cell carcinoma. PMID: 22511601
  7. HCCR-1 might play a role in the breast tumourigenesis while the overexpression of HCCR-1 induces the obesity probably by inhibiting the cholesterol-lowering effect of ApoE PMID: 20196787
  8. The overexpression of HCCR-2 could enhance the division and proliferation of SMMC 7721 cells. PMID: 21138632
  9. induces neoplastic cell transformation and epithelial-mesenchymal transdifferentiation PMID: 20591135
  10. Treatment of PANC-1 cells with epidermal growth factor increased HCCR-1 protein level via PI3K/Akt/mTOR signaling. PMID: 20423485
  11. Human, similar to bacterial ribosomal protein L14 and yeast L22, gene L14.22 (clone 507E08), over-expressed in gliomas. PMID: 12061725
  12. HCCR-2 probably represents a new oncogene that is related to tumorigenesis, functioning as a negative regulator of the p53 tumor suppressor PMID: 12879013
  13. HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor. PMID: 14691448
  14. HCCR oncoprotein has a role in development of human breast cancer PMID: 16278390
  15. These results suggest that the HCCR-1 oncogene expression was regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway. PMID: 16949218
  16. These experiments show the biological features of HCCR-1 in the cell, and suggest that uncontrolled expression of HCCR-1 may cause mitochondrial dysfunction. PMID: 18045496
  17. Data indicate that the level of HCCR-1 in breast cancer tissues is correlated with the HER2 overexpression, p53 mutation, and ER/PR status, and determination of HCCR-1 levels as options for HER2 testing is promising although it needs further evaluation. PMID: 19208263
  18. TCF and beta-catenin binding plays important roles in HCCR-1 oncogene expression. PMID: 19435525

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Subcellular Location
Mitochondrion outer membrane; Single-pass membrane protein.
Tissue Specificity
Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix.
Database Links

HGNC: 24241

KEGG: hsa:25875

STRING: 9606.ENSP00000262055

UniGene: Hs.655272

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