LGI4 Antibody

Code CSB-PA818678LA01HU
Size US$166
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Image
  • IHC image of CSB-PA818678LA01HU diluted at 1:200 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA818678LA01HU diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LGI4 Polyclonal antibody
Uniprot No.
Target Names
LGI4
Alternative Names
Leucine rich glioma inactivated gene 4 antibody; Leucine rich glioma inactivated protein 4 antibody; Leucine rich repeat LGI family member 4 antibody; Leucine-rich glioma-inactivated protein 4 antibody; Leucine-rich repeat LGI family member 4 antibody; LGI1 like protein 3 antibody; LGI1-like protein 3 antibody; LGI4 antibody; Lgi4 protein antibody; LGI4_HUMAN antibody; Lgil3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Leucine-rich repeat LGI family member 4 protein (292-412AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The LGI4 Antibody (Product code: CSB-PA818678LA01HU) is Non-conjugated. For LGI4 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA818678LB01HU LGI4 Antibody, HRP conjugated ELISA
FITC CSB-PA818678LC01HU LGI4 Antibody, FITC conjugated
Biotin CSB-PA818678LD01HU LGI4 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation.
Gene References into Functions
  1. in four unrelated multiplex families presenting with severe arthrogryposis multiplex congenital, identified biallelic loss-of-function mutations in LGI4; functional tests showed these germline mutations caused aberrant splicing of the endogenous LGI4 transcript and in a cell-based assay impaired the secretion of truncated LGI4 protein PMID: 28318499
  2. Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals. PMID: 24662834
  3. The positive genotypic association between benign familial infantile convulsions (BFIC)and c.1722G/A polymorphism suggests that LGI4 might contribute to the susceptibility to BFIC. PMID: 19815358
  4. Schwann cells are the principal cellular source of Lgi4 in the developing nerve; transgenic Lgi4 binds directly to Adam22 without a requirement for additional membrane associated factors. PMID: 20220021
  5. Screening of the LGI4 coding region in BFIC and childhood absence epilepsy (CAE) revealed several frequent exonic polymorphisms. PMID: 14505228

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Involvement in disease
Arthrogryposis multiplex congenita, neurogenic, with myelin defect (AMCNMY)
Subcellular Location
Secreted.
Tissue Specificity
Widely expressed, with highest expression in brain.
Database Links

HGNC: 18712

OMIM: 608303

KEGG: hsa:163175

STRING: 9606.ENSP00000312273

UniGene: Hs.65256

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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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