LGI4

LGI4 encodes the leucine-rich repeat and LGI domain-containing protein 4, a member of the LGI family with no widely recognized aliases. It mediates cell-cell interactions and signal transduction via its conserved domains, interacting with ADAM metalloproteases to regulate axon guidance and peripheral nerve myelination.
Dysregulation of LGI4 is linked to peripheral neuropathies like Charcot-Marie-Tooth disease-like phenotypes, resulting from impaired nerve fiber development. Current research focuses on its role in Schwann cell function; no targeted drugs are in clinical trials, but preclinical studies explore its potential for nerve regeneration therapies.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LGI4 Antibody (CSB-PA818678LA01HU)

Validated Data

IHC image of CSB-PA818678LA01HU diluted at 1:200 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA818678LA01HU diluted at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

The following LGI4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

LGI4 Antibodies

LGI4 Proteins

LGI4 Antibodies

LGI4 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA818678LA01HU	LGI4 Antibody	Human	ELISA, IHC
CSB-PA818678LB01HU	LGI4 Antibody, HRP conjugated	Human	ELISA
CSB-PA818678LC01HU	LGI4 Antibody, FITC conjugated	Human
CSB-PA818678LD01HU	LGI4 Antibody, Biotin conjugated	Human	ELISA

LGI4 Proteins

LGI4 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP818678HU CSB-BP818678HU CSB-MP818678HU CSB-EP818678HU-B	Recombinant Human Leucine-rich repeat LGI family member 4 (LGI4)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP818678HU	Recombinant Human Leucine-rich repeat LGI family member 4 (LGI4)	E.coli

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LGI4

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