LGR6 Antibody, HRP conjugated

Datasheet

Code	CSB-PA884515LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LGR6 Polyclonal antibody

Uniprot No.

Q9HBX8

Target Names

LGR6

Alternative Names

FLJ14471 antibody; Gonadotropin receptor antibody; GPCR antibody; Leucine rich repeat containing G protein coupled receptor 6 antibody; Leucine-rich repeat-containing G-protein coupled receptor 6 antibody; Lgr6 antibody; LGR6_HUMAN antibody; VTS20631 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 6 protein (839-962AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.

Gene References into Functions

Inhibition of LGR6 promoted the osteogenic differentiation of bone marrow stromal cells in vitro. PMID: 29625528
Lgr6 has a tumorpromoting role in the development of colorectal cancer. PMID: 29693156
Lgr6 marks mammary gland progenitor cells that can initiate tumours, and cells of luminal breast tumours required for efficient tumour maintenance. PMID: 27798604
Two of the three monoclonal antibodies recognized the large N-terminal extracellular domain of leucine rich repeat containing G protein-coupled receptor 6 (LGR6), and competitively blocked the binding of R-spondin 1, which is known to be the ligand for LGR6. PMID: 28013222
LGR6 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
Overexpression of wild-type LGR6 in HeLa cells leads to increased cell migration. PMID: 22615920

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 1 family

Database Links

HGNC: 19719

OMIM: 606653

KEGG: hsa:59352

STRING: 9606.ENSP00000356247

UniGene: Hs.497402

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Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

G protein coupled receptor signaling pathway Target Therapy

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