LGR6 Antibody

Code CSB-PA884515LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: U87 whole cell lysate
    All lanes: LGR6 antibody at 2.5µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 105, 90, 100 kDa
    Observed band size: 105 kDa

  • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA884515LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA884515LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LGR6 Polyclonal antibody
Uniprot No.
Target Names
LGR6
Alternative Names
FLJ14471 antibody; Gonadotropin receptor antibody; GPCR antibody; Leucine rich repeat containing G protein coupled receptor 6 antibody; Leucine-rich repeat-containing G-protein coupled receptor 6 antibody; Lgr6 antibody; LGR6_HUMAN antibody; VTS20631 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 6 protein (839-962AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The LGR6 Antibody (Product code: CSB-PA884515LA01HU) is Non-conjugated. For LGR6 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA884515LB01HU LGR6 Antibody, HRP conjugated ELISA
FITC CSB-PA884515LC01HU LGR6 Antibody, FITC conjugated
Biotin CSB-PA884515LD01HU LGR6 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.
Gene References into Functions
  1. Inhibition of LGR6 promoted the osteogenic differentiation of bone marrow stromal cells in vitro. PMID: 29625528
  2. Lgr6 has a tumorpromoting role in the development of colorectal cancer. PMID: 29693156
  3. Lgr6 marks mammary gland progenitor cells that can initiate tumours, and cells of luminal breast tumours required for efficient tumour maintenance. PMID: 27798604
  4. Two of the three monoclonal antibodies recognized the large N-terminal extracellular domain of leucine rich repeat containing G protein-coupled receptor 6 (LGR6), and competitively blocked the binding of R-spondin 1, which is known to be the ligand for LGR6. PMID: 28013222
  5. LGR6 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
  6. Overexpression of wild-type LGR6 in HeLa cells leads to increased cell migration. PMID: 22615920

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Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Database Links

HGNC: 19719

OMIM: 606653

KEGG: hsa:59352

STRING: 9606.ENSP00000356247

UniGene: Hs.497402

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