LHCGR Antibody

Code CSB-PA012911GA01HU
Size US$685
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Product Details

Uniprot No. P22888
Target Names LHCGR
Alternative Names Gonadotropin receptor antibody; Gpcr19-rs1 antibody; GTHR-II antibody; HHG antibody; LCGR antibody; LGR2 antibody; LH-R antibody; LH/CG R antibody; LH/CG-R antibody; LH/CGR antibody; LHCGR antibody; LHR antibody; LHRHR antibody; LSH R antibody; LSH-R antibody; LSHR_HUMAN antibody; Luteinizing hormone receptor antibody; Luteinizing hormone/choriogonadotropin receptor antibody; Lutropin choriogonadotropic hormone receptor antibody; Lutropin choriogonadotropic receptor antibody; Lutropin-choriogonadotropic hormone receptor antibody; ULG5 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human LHCGR
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB,IHC
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Receptor for lutropin-choriogonadotropic hormone
Gene References into Functions
  1. This study demonstrates that both gonadotrophin receptors9 FSH receptor (FSHR) and LH/choriogonadotrophin receptor (LHCGR) are expressed along the glandular epithelium of endometria and they mediate the effects of gonadotrophins on intracellular functions. PMID: 29974367
  2. Genotyping analysis showed no association between luteinizing hormone receptor (LHCGR) rs68073206 and male infertility, however, this polymorphism was significantly associated with testosterone levels in normozoospermic subjects. PMID: 28367994
  3. Data suggest that, during follicle maturation, levels of MIR122 determine levels of LHR mRNA expression in the ovary. (LHR = luteinizing hormone receptor; MIR122 = microRNA 122) [REVIEW] PMID: 29544643
  4. genetic association/pharmacogenetic studies in population in India: Data suggest that need for (and dose required of) fertility agent recombinant LH in addition to fertility agent recombinant FSH is associated with SNP in LHCGR in women undergoing ovarian stimulation in conjunction with in vitro fertilization. (LH = luteinizing hormone; FSH = follicle stimulating hormone) PMID: 29408742
  5. hCG and its receptor, LH/CGR, are expressed in numerous sites of the reproductive tract, both in gonadal and extra-goanadal tissues, promoting oocyte maturation, fertilization, implantation and early embryo development PMID: 28505106
  6. The reduced fertilisation and pregnancy rate was associated with a lower LH receptor density and a lack of essential down-regulation of the FSH and LH receptor. PMID: 28188844
  7. This work demonstrates that the expression of FSHR and LHCGR can be induced in hGL5 cells but that the FSHR-dependent cAMP/PKA pathway is constitutively silenced, possibly to protect cells from FSHR-cAMP-PKA-induced apoptosis. PMID: 27502035
  8. Inactivating mutations of the LHCGR gene may be a common cause of 46,XY primary amenorrhea. PMID: 27016457
  9. data demonstrate that the majority of LHR mutations lead to intracellular retention and highlight the potential for novel pharmacological chaperone therapeutics that can "rescue" expression/function of retained mutant GPCRs. PMID: 27533885
  10. expression and activation of LHCGR and ARF6 are up-regulated in GC from PCOS women but the mechanism of agonist-induced LHCGR internalization is unaltered PMID: 27061682
  11. We showed that GNRHR and LHCGR were highly expressed in some wildtype aldosterone-producing adenoma samples, and that they positively correlated with GnRH-stimulated aldosterone production. PMID: 27196470
  12. Mutation in the LHCGR gene is associated with Testotoxicosis. PMID: 26757946
  13. The luteinizing hormone/human chorionic gonadotrophin receptor (LHCGR) variant N312S and the follicle-stimulating hormone receptor (FSHR) variant N680S can be utilized for the prediction of pregnancy chances in women undergoing IVF. PMID: 26769719
  14. Data indicate two patients with peripheral precocious puberty and an activating mutation in the luteinizing hormone (LH))/choriogonadotropin receptor (LHCGR) gene. PMID: 26831561
  15. The expression of miR-592 and its effects on LHCG receptors in patients with polycystic ovary syndrome and normal controls are described. PMID: 26679164
  16. LHCGR levels in circulation predicts early and late preeclampsia in first trimester of pregnancy. PMID: 25676660
  17. Data suggest that rs13405728 single nucleotide polymorphism of the luteinizing hormone receptor (LHR) gene may be associated with slow ovarian response in assisted reproductive technology (ART). PMID: 26663062
  18. The insLQ polymorphism within LHR is associated with endometriosis and infertility. PMID: 25935136
  19. the LHR can act in an invertebrate demonstrates the conservation of factors required for GPCR function among phylogenetically distant organisms. PMID: 26112185
  20. Demonstrate the presence of LH receptors. Activation resulted in a dose-dependent increase in glucose-induced release of insulin. PMID: 25670721
  21. Our aim was to study the association of LHCGR polymorphism (rs2293275) with PCOS PMID: 25565299
  22. Melatonin affects the secretion of GnRH, LH and testosterone, improves sperm quality thereby regulating the testicular development and male reproduction. (Review) PMID: 25916694
  23. This is the first study to confirm the association of novel LHCGR and FSHR SNPs with PCOS. The differential association of LHCGR and FSHR variants with PCOS confirms the racial/ethnic contribution to their association with PCOS. PMID: 25649397
  24. Case Report: LHCGR nonsense mutation in an adult 46,XY female patient causing severe Leydig cell hypoplasia. PMID: 25079470
  25. A high prevalence of endometriosis, polymorphism in the LHCGR and GnRH1 and progonadoliberin-2 antibodies in serum was found among the patients with severe dysmotility after treatment with GnRH analogs. PMID: 25592315
  26. affected patients were all homozygous for a novel mutation in the LHCGR gene, a deletion of guanine in position 1850 (1850delG);the novel LHCGR mutation leads to complete inactivation of the LHCGR receptor due to trafficking and signaling abnormalities PMID: 25795638
  27. Data indicate that all solid pseudopapillary tumor of the pancreas {SPT) presented membranous and cytoplasmic staining for luteinizing hormone receptor (LH receptor). PMID: 25010708
  28. Data suggest LHR expression is up-regulated in granulosa cells and theca cells of early antral follicles, as follicles grow/mature, and in corpus luteum; low but significant expression of LHR is exhibited in cumulus cells (but not in stromal cells). PMID: 24874553
  29. this is the first report suggesting that LHCGR genetic variation might function in patient risk for ovarian hyperstimulation syndrome PMID: 23883350
  30. Silencing luteinizing hormone receptor expression suppresses androgen synthesis in prostate cancer cells. PMID: 25393079
  31. genetic association study (case-control study) in population in Egypt: Data suggest that an SNP in LHCGR (rs2293275) is associated with polycystic ovary syndrome (PCOS); homozygous 935A women are at higher risk to develop PCOS. PMID: 24592983
  32. miR-513a-3p is involved in the control of the LHCGR expression by an inversely regulated mechanism at the post-transcriptional level. PMID: 24747085
  33. Data (including data from subjects with mutations) suggest that signaling via LHCGR by luteinizing hormone and chorionic gonadotropin plays physiological roles in human development and pathophysiological roles in reproductive disorders. [REVIEW] PMID: 24283620
  34. during recovery from LH receptor desensitization, LH receptors are both located with DRM lipid environments and confined within small, mesoscale (80-160 nm) cell-surface compartments PMID: 23990106
  35. Although luteinizing hormone and chorionic gonadotropin bind to a common receptor, emerging evidence suggests that they have disparate effects on downstream signaling cascades. (Review) PMID: 24365330
  36. results of the experiments showed that hCGbeta action leads to the increase in ERK and AKT kinases phosphorylation in cancer cells and indicate that these biological effects can be achieved independently of human chorionic gonadotropin presence PMID: 24554412
  37. LHCGR and 17alpha-hydroxylase/17-20-lyase (CYP17A1) protein levels are increased in polycystic ovaries (PCOs). PMID: 24014605
  38. Regarding LHR, three patients were heterozygous for the known variant Glu354Lys and two for Ile374Thr. Intronic polymorphisms were not identified PMID: 23884663
  39. hypomethylation of LHCGR is a potential mechanism underlying susceptibility to polycystic ovary syndrome PMID: 24527662
  40. Examined the mechanisms of receptor signaling, intermolecular cooperation and intramolecular cis-activation. LHR-delExon10 was combined with LHR Lys605-->Glu, in which signaling is abolished, and the LHR mutant Cys131-->Arg, in which binding is deficient. PMID: 24438591
  41. AdipoR2 is regulated by the LH receptor function via a cAMP dependent mechanism. PMID: 23779096
  42. High expression/ activation of GPER, and low expression of LHCGR/FSHR correlate with significantly greatly survival in ovarian epithelial cancer patients. PMID: 23951246
  43. Expression levels of LHR-associated protein are determined in granulosa-luteal cells by real-time reverse-transcription (PCR). PMID: 23433069
  44. Data suggest that physical association of recombinant LHR (lutropin receptor) and FSHR (follitropin receptor) into heterodimeric complexes exhibits a pattern of cross-attenuation of signaling by each receptor and its hormone. PMID: 23825122
  45. A complex neuroendocrine circuit exists in the retina, involving hCG secreting cells, hCG targets and hCG-release controlling cells. PMID: 23285091
  46. case-control study comprising 651 TC cases and 313 controls in a Norwegian population was conducted for investigation of polymorphisms in the LHR, SRD5A and AR genes and their possible association with TC PMID: 22882535
  47. The LHCGR is able to differentiate the activity of luteinizing hormone and chorionic gonadotropin. PMID: 23071612
  48. A novel point mutation of the LHCGR gene has been identified in a family affected with FMPP. The c.1703C>T mutant LHCGR was confirmed to be constitutively active, which has led to maturation and proliferation of Leydig cells. PMID: 23225038
  49. Mutations in LHCGR are relatively rare causes of mild and severe forms of hypergonadotropic hypogonadism or disorders of sex development leading to infertility, both male and female. [REVIEW] PMID: 23044874
  50. The gene products LHCGR and FSHR therefore are likely to be important in the etiology of PCOS, regardless of ethnicity. PMID: 23118426
  51. Our results suggest that SNPs rs2479106 in gene DENND1A and rs13405728 in gene LHCGR are associated with endometrioid adenocarcinoma. PMID: 22902918
  52. The LHR rs61996318 SNP maybe highly conserved in Chinese Han women. PMID: 22546001
  53. The LHR gene is expressed in granulosa cell of human antral follicles throughout the follicular phase and is significantly associated with expression of the CYP19a1 gene. PMID: 22659248
  54. The average expression of AMH was significantly higher in egg donors and the average expression of LHCGR was significantly higher in DOR patients. PMID: 22355044
  55. The results suggest that polymorphisms in ESR1, ESR2 and LHCGR contribute to the risk of developing testicular germ cell cancer, histological subtype, and risk to metastasis. PMID: 22245602
  56. The presence of at least one 312N allele was strongly associated with polycystic ovary syndrome risk. PMID: 22356187
  57. The results indicated that LHR-Del7 does not have negative effect on LHR-WT cell surface expression, and although the pathological splicing variant LHR-Del7 was able to localize to cell membranes it failed to bind hCG and had no effect on wild-type LHR. PMID: 22002533
  58. Case Report: heterozygous inactivating mutation in the LHCGR gene associated with amenorrhea, low oocyte yield, and recurrent pregnancy loss. PMID: 22369774
  59. Data report two antibodies, scFv 13B1 and MAb PD1.37, against the hinge regions of LHR and TSHR, respectively, which have similar epitopes but different effects on receptor function. PMID: 22309849
  60. High expression of luteinizing hormone receptors messenger RNA by human cumulus granulosa cells is in correlation with decreased fertilization. PMID: 22260850
  61. FSH and LH receptors were found in normal postmenopausal ovaries PMID: 22207559
  62. Paper describes the first application of prenatal diagnosis in LHCGR deficiency for 46,XY disorders of sex development with the subsequent delivery of a normal baby. PMID: 21720050
  63. the structurally uncharacterized C-terminal domain of LHR extracellular domain can no longer be considered to be an inert structural element of the receptor PMID: 21989932
  64. C terminus of Galpha(s) was found to be necessary for LHR and beta(2)-AR signaling. PMID: 21622536
  65. the somatic D578H-LHR mutation in the LHR gene was observed in the majority of the patients with Leydig cell adenoma and in a patient with nodular Leydig cell hyperplasia in both testes PMID: 21490077
  66. Ovarian cancer cells transfected to express functional LHR showed the differential expression of 1,783 genes in response to LH treatment. PMID: 21711548
  67. Restricted lateral diffusion of luteinizing hormone receptors in membrane microdomains. PMID: 21690095
  68. Cultured human early pregnancy placental explants also released LHCGR via microvesicles. PMID: 21575145
  69. Case Report: Mutation impairing the function of LHCGR may be responsible for empty follicle syndrome. PMID: 21683950
  70. data show that LH-regulated ERK1/2 signaling is required for the LRBP-mediated down-regulation of LHR mRNA PMID: 21147848
  71. This review is intended to provide a brief, general overview of LHCGR. PMID: 20374734
  72. findings demonstrated a critical aspect of LHR modulation whereby PC4 acts as a coactivator of Sp1 to contribute to the human of LHR transcription PMID: 21193408
  73. Results identify key amino acids that are part of the regulatory network responsible for propagating communication between the extracellular and intracellular poles of the luteinizing hormone receptor. PMID: 20835841
  74. Data suggest that a subset of patients with primary aldosteronism has aberrant LHR and GNRHR expression, which could modulate aldosterone secretion. PMID: 21330483
  75. recent advances in our understanding of LHR structure and structure-function [REVIEW] relationships, as well as hormone-mediated changes in gene expression in ovarian cancer cells PMID: 20444430
  76. chronically elevated levels, along with unknown genetic and epigenetic changes, may also lead to the formation of tumors that can secrete all three major classes of adrenal steroid hormones PMID: 20646984
  77. [review] LHR expression in the ovary is regulated by a post-transcriptional mechanism mediated by mevalonate kinase thereby linking LHR expression with cholesterol metabolism. PMID: 20570710
  78. Higher adiposity and younger gynecological age predict rapid luteinizing hormone secretion with increased pulse frequency. [2] The early years after menarche represent a vulnerable window for an exaggerated LHPF with weight gain. PMID: 19394610
  79. Results confirm the fact that somatic activating mutations of gonadotropin receptors are involved in gonadal tumorigenesis. PMID: 11857565
  80. review of the mechanism of desensitization to LH mediated by extensive clustering and internalization of the LH hormone-receptor complex PMID: 11988313
  81. Cis- and trans-activation of hormone receptors: the LH receptor PMID: 12040016
  82. Evidence that luteinising hormone receptor polymorphisms may contribute to male undermasculinisation. PMID: 12088926
  83. HDAC-Sin3A complex regulates LHR Gene transcription PMID: 12091390
  84. study of the conformations of the active and inactive states of the hLHR PMID: 12242044
  85. LH receptor gene expresses in normal endometrium at very low levels, and at increased levels in endometrial cancerous tissues compared with surrounding microscopically normal tissues PMID: 12270268
  86. Homozygous mutation within the conserved Ala-Phe-Asn-Glu-Thr motif of exon 7 of the LH receptor causes male pseudohermaphroditism. PMID: 12444891
  87. Structure of LH receptor based on molecular modeling and the supporting experimental data from engineered and naturally occurring mutations. (review) PMID: 12450321
  88. LH-responsive Cushing's syndrome, associated with bilateral adrenal hyperplasia, may result from aberrant (or possibly increased) adrenal LH receptor expression. PMID: 12519858
  89. findings suggest that the luteinizing hormone receptor 18insLQ gene polymorphism determines an earlier age of disease onset and is prognostic for poor outcome of breast cancer PMID: 12679452
  90. although exon 10 of the luteinizing hormone receptor plays no role in ligand binding, it is important for receptor activation by LH by a mechanism probably involving extracellular conformational changes PMID: 12727981
  91. Point mutations in the hinge region or ligand binding could cause conformational changes in the transmembrane region that result in Gs activation. PMID: 12770743
  92. In human ovaries, MAb found 6 distinct LHR bands migrating at approximately 92, 80, 68, 59, 52 & 48 kDa. There is a possible role for LHR in the development of abnormal pregnancy, pelvic floor disorders & Alzheimer's disease. PMID: 12816543
  93. human cervix contains functional LH/hCG receptors, which suggests that LH during the menstrual cycle and hCG during pregnancy may regulate cervical functions. PMID: 12843195
  94. results of mutagenesis and buffer studies suggest that electrostatic effects contribute to ligand binding and/or that the LHR ectodomain may exist in two conformations, one being more accessible to ligand at reduced ionic strength. PMID: 12850276
  95. the G proteins activated by constitutively active mutants of the hLHR associated with Leydig cell hyperplasia or tumors are identical and are the same as those activated by the agonist-engaged hLHR-wt. PMID: 12933660
  96. The LHR gene promoter is repressed by cross talk among the transcription factors EAR3, SP1 and TFIIB. PMID: 12972613
  97. characterization of interaction with GAIP-interacting protein C terminus PMID: 14507927
  98. cell surface human lutropin receptor self-associates PMID: 14594799
  99. a novel, noncontiguous, transferable motif that participates in the sorting of internalized G protein-coupled receptors PMID: 14605099
  100. Fetal kidney, liver, pancreas, lung, small and large intestines, and adrenals contained hCG/LH receptors. May mediate pleiotropic actions of hCG in growing human fetus. PMID: 14764820

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Involvement in disease Familial male precocious puberty (FMPP); Luteinizing hormone resistance (LHR)
Subcellular Location Cell membrane, Multi-pass membrane protein
Protein Families G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily
Tissue Specificity Gonadal and thyroid cells.
Database Links

HGNC: 6585

OMIM: 152790

KEGG: hsa:3973

STRING: 9606.ENSP00000294954

UniGene: Hs.468490

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