LHX2 Antibody

1. These data indicate that Lhx2 is capable of blocking proliferation of T-ALL-derived cells by both LMO2-dependent and -independent means. We propose Lhx2 as a new molecular tool for anti-T-ALL drug development. PMID: 29278703
2. Findings demonstrate that miR-1238 inhibit the proliferation of NSCLC cells at least partly via repression of LHX2, shedding light on the mechanistic interaction of miR-1238 and LHX2 in NSCLC carcinogenesis. PMID: 26189214
3. Results show that LHX2 is overexpressed in pancreatic ductal adenocarcinoma cells and is involved in promoting cancer cell proliferation and enhanced tumor development. PMID: 25324171
4. Lhx2 directly regulates tanycyte specification and differentiation in the hypothalamus. PMID: 25505333
5. This study demonistrated that LHx2 regulates the development of the forebrain hem system. PMID: 23307637
6. The data indicate a dual role of Lhx2 during EMT and tumor progression: by inducing the expression of PDGF-B, Lhx2 provokes an autocrine PDGF-B/PDGFRbeta loop required for cell migration, invasion and metastatic dissemination PMID: 24423492
7. The findings indicate that LHX2 regulates the transcription of downstream intrinsic and extrinsic molecules that are essential for early neural differentiation. PMID: 23804753
8. These results suggest that if LHX2 is involved in pituitary hormone deficiency associated with posterior pituitary and ocular defects, it would be a rare cause of this disease condition. PMID: 22535646
9. Mutations in LHX2 do not represent a frequent cause of micro/anophthalmia. PMID: 21203406

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HGNC: 6594

OMIM: 603759

KEGG: hsa:9355

STRING: 9606.ENSP00000362717

UniGene: Hs.696425