LIN7B Antibody

Datasheet

Code	CSB-PA012964GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9HAP6

Target Names

LIN7B

Alternative Names

hVeli2 antibody; hLin7B antibody; hVeli2 antibody; Lin 7 homolog B C elegans antibody; LIN 7B antibody; Lin 7b protein likely ortholog of mouse LIN 7B mammalian LIN 7 protein 2 antibody; Lin-7B antibody; LIN7B antibody; LIN7B_HUMAN antibody; MALS 2 antibody; MALS-2 antibody; MALS2 antibody; Mammalian lin seven protein 2 antibody; Mammalian lin-seven protein 2 antibody; Protein lin 7 homolog B antibody; Protein lin-7 homolog B antibody; VELI 2 antibody; Veli-2 antibody; VELI2 antibody; Vertebrate lin 7 homolog 2 antibody; Vertebrate lin-7 homolog 2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human LIN7B

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface.

Gene References into Functions

functional deficiency in Lin-7B could be implicated in clinical phenotypes in some autism spectrum disorders patients through bringing about abnormal cortical architecture PMID: 25196215
Data suggest that decreased cortical LIN7b expression may contribute to abnormal corticostriatal connectivity in Huntington disease. PMID: 20720508
LIN7B is a partner of IRSp53 anchoring the actin-based membrane cytoskeleton at cell-cell contacts. PMID: 14596909
PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current PMID: 15317815
Lin-7B is a binding partner for Rhotekin in the human brain cDNA library PMID: 16979770

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Subcellular Location

Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Cell junction, synapse, postsynaptic density membrane; Peripheral membrane protein. Cell junction, tight junction.

Protein Families

Lin-7 family

Database Links

HGNC: 17788

OMIM: 612331

KEGG: hsa:64130

STRING: 9606.ENSP00000221459

UniGene: Hs.221737

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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