LIN9 Antibody

Datasheet

Code	CSB-PA716370LA01HU
Size	US$166
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Image	IHC image of CSB-PA716370LA01HU diluted at 1:800 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LIN9 Polyclonal antibody

Uniprot No.

Q5TKA1

Target Names

LIN9

Alternative Names

BARA antibody; Beta subunit-associated regulator of apoptosis antibody; Beta-subunit associated regulator of apoptosis antibody; hLin-9 antibody; huLin-9 antibody; lin-9 antibody; lin9 antibody; LIN9_HUMAN antibody; pRB-associated protein antibody; Protein lin-9 homolog antibody; TGS antibody; TUDOR gene similar protein antibody; Type I interferon receptor beta chain-associated protein antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein lin-9 homolog protein (5-103AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The LIN9 Antibody (Product code: CSB-PA716370LA01HU) is Non-conjugated. For LIN9 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA716370LB01HU	LIN9 Antibody, HRP conjugated	ELISA
FITC	CSB-PA716370LC01HU	LIN9 Antibody, FITC conjugated
Biotin	CSB-PA716370LD01HU	LIN9 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.

Gene References into Functions

High LIN9 expression is associated with Triple-negative breast cancers. PMID: 28807940
The MuvB multiprotein complex, together with B-MYB and FOXM1 (MMB-FOXM1) regulate the expression of mitotic kinesins in breast cancer cells. PMID: 28061449
LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression. PMID: 24475316
Results show that E7 interacts with the B-Myb, FoxM1 and LIN9 components of this activator complex, leading to cooperative transcriptional activation of mitotic genes in primary cells and E7 recruitment to the corresponding promoters. PMID: 24141769
Study links hTRM9L and tRNA modifications to inhibition of tumour growth via LIN9 and HIF1-alpha-dependent mechanisms. PMID: 23381944
inactivation of LIN9, a subunit of DREAM, results in premature senescence, which can be overcome by the SV40 large T (LT) antigen PMID: 21860417
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20360844
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
Human Lin-9 has tumor-suppressing activities and the ability of hLin-9 to inhibit transformation is mediated through its association with pRB. PMID: 15538385
Mutation of BARA/LIN-9 restores the expression of E2F target genes. PMID: 16730350
Mip/LIN-9 is required for the expression of B-Myb, and both proteins collaborate in the control of the cell cycle progression via the regulation of S phase and cyclin A, cyclin B, and CDK1 PMID: 17098733
human LIN-9, together with B-MYB, has a critical role in the activation of genes that are essential for progression into mitosis PMID: 17159899
The repressor complex that Mip/LIN-9 forms with p107 takes functional precedence over the transcriptional activation linked to the Mip/LIN-9 and B-Myb interaction. PMID: 17563750

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Subcellular Location

Nucleus, nucleoplasm. Note=Found in perinucleolar structures. Associated with chromatin.

Protein Families

Lin-9 family

Tissue Specificity

Expressed in thymus and testis.

Database Links

HGNC: 30830

OMIM: 609375

KEGG: hsa:286826

STRING: 9606.ENSP00000329102

UniGene: Hs.120817

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Cellular senescence

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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