LONP2 Antibody

Code CSB-PA060279
Size US$100
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Product Details

Uniprot No.
Target Names
LONP2
Alternative Names
Lon peptidase 2, peroxisomal antibody; Lon protease 2 antibody; Lon protease homolog 2 antibody; Lon protease homolog 2 peroxisomal antibody; Lon protease like protein 2 antibody; Lon protease-like protein 2 antibody; LONP antibody; lonp2 antibody; LONP2_HUMAN antibody; LONPL antibody; MGC4840 antibody; peroxisomal antibody; Peroxisomal Lon protease antibody; Peroxisomal Lon protease homolog 2 antibody; Peroxisomal LON protease like antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the C-terminal region of Human LONP2.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
Gene References into Functions
  1. Findings suggest that LONP2 promotes cervical tumorigenesis via oxidative stress. PMID: 29502128
  2. The proteolytic activity of oligomeric Tysnd1 is in turn controlled by self-cleavage of Tysnd1 and degradation of Tysnd1 cleavage products by PsLon. PMID: 22002062
  3. Lon recognizes specific surface determinants or folds, initiates proteolysis at solvent-accessible sites of MPPalpha and StAR, and generates unfolded polypeptides that are then processively degraded PMID: 15870080
Subcellular Location
Peroxisome matrix.
Protein Families
Peptidase S16 family
Tissue Specificity
Widely expressed, with high levels in the liver, kidney and pancreas.
Database Links

HGNC: 20598

OMIM: 617774

KEGG: hsa:83752

STRING: 9606.ENSP00000285737

UniGene: Hs.295923

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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