LRRFIP2 Antibody, HRP conjugated

Datasheet

Code	CSB-PA896921LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LRRFIP2 Polyclonal antibody

Uniprot No.

Q9Y608

Target Names

LRRFIP2

Alternative Names

5133400F20Rik antibody; AI850587 antibody; DKFZp434H2035 antibody; FLJ20248 antibody; FLJ22683 antibody; FLJ58304 antibody; HUFI 2 antibody; Leucine rich repeat (in FLII) interacting protein 2 antibody; Leucine rich repeat flightless interacting protein 2 antibody; Leucine-rich repeat flightless-interacting protein 2 antibody; LRR FLII interacting protein 2 antibody; LRR FLII-interacting protein 2 antibody; LRRF2_HUMAN antibody; Lrrfip2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Leucine-rich repeat flightless-interacting protein 2 protein (211-342AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.

Gene References into Functions

Data show that the ability of Ca(2+) to accentuate the activity of NLRP3 inflammasome is abrogated in Flightless-I (FliI) and leucine-rich repeat FliI-interaction protein 2 (LRRFIP2)-knockdown macrophages. PMID: 27431477
FATylation of LRRFIP2 occurs on two distinct sites, each being modified by a single FAT10 moiety. PMID: 23036196
A novel exonic rearrangement affecting MLH1 and the contiguous LRRFIP2 is a founder mutation in Portuguese Lynch syndrome families PMID: 21785361
Unambiguous characterization of site-specific phosphorylation of leucine-rich repeat Fli-I-interacting protein 2 (LRRFIP2) in Toll-like receptor 4 (TLR4)-mediated signaling. PMID: 21220426
These data suggest that LRRFIP2 plays an important role in transducing Wnt signals. PMID: 15677333
LRR-binding MyD88 interactor LRRFIP2 is a positive regulator of NF-kappa B activity and is also a positive regulator of cytokine production in lipopolysaccharide-stimulated macrophages, suggesting a functional role in TLR4-mediated inflammatory response. PMID: 19265123

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Protein Families

LRRFIP family

Tissue Specificity

Widely expressed, with highest levels in heart and skeletal muscle.

Database Links

HGNC: 6703

OMIM: 614043

KEGG: hsa:9209

STRING: 9606.ENSP00000338727

UniGene: Hs.740522

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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