LRRTM1 Antibody

1. Continuity between schizophrenia and schizotypy exists with regard to the psychological effects of allelic variation in LRRTM1, and epigenetic variation in the imprinted gene mediates the development and expression of human handedness. PMID: 24785688
2. Hypomethylation of the paternally inherited LRRTM1 promoter is linked to schizophrenia. PMID: 25111784
3. CTNNA1 and CTNNA2 contain alternative 5' exons linked to bidirectional promoters that are shared with the antisense oriented LRRTM2 and LRRTM1 genes, respectively. PMID: 21708131
4. 16 SNPs in 12 genes showed significant interaction at P < .05, 3 of which survived correction for multiple testing (P < .0003), situated in AKT1 (rs2494732 and rs1130233) and LRRTM1 (rs673871). PMID: 21041608
5. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 21041608
6. Observational study of gene-disease association. (HuGE Navigator) PMID: 20678249
7. LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. PMID: 17667961
8. Whether or not LRRTM1 on chromosome 2p12 is indeed the genetic basis of handedness is still unclear, although the controversy of the claim seems indisputable. PMID: 19125365
9. While we agree (and indeed first proposed) that the variation underlying psychosis is intrinsically related to the cerebral torque, which we take to be the anatomical basis of language, we are unconvinced by the data for LRRTM1. PMID: 19125366
10. Recent study in which the first putative genetic effect on human handedness was identified (the imprinted locus LRRTM1 on human chromosome 2). PMID: 19125367
11. Results strengthen the evidence for an association of imprinted alleles of LRRTM1 with schizophrenia. Weaker supportive evidence was also obtained for a possible association of LRTTM1 with human brain asymmetry. PMID: 19626025

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HGNC: 19408

OMIM: 610867

KEGG: hsa:347730

STRING: 9606.ENSP00000295057

UniGene: Hs.591580