LSM14A Antibody

Code CSB-PA013203GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
LSM14A
Alternative Names
AlphaSNBP antibody; C19orf13 antibody; Chromosome 19 open reading frame 13 antibody; DKFZp434D1335 antibody; FAM61A antibody; Family with sequence similarity 61 member A antibody; hRAP55 antibody; hRAP55A antibody; LS14A_HUMAN antibody; LSM14 homolog A (SCD6 S cerevisiae) antibody; LSM14 homolog A antibody; LSM14A antibody; Protein FAM61A antibody; Protein LSM14 homolog A antibody; Protein SCD6 homolog antibody; Putative alpha synuclein binding protein antibody; Putative alpha-synuclein-binding protein antibody; RAP55 antibody; RNA associated protein 55 antibody; RNA-associated protein 55A antibody; SCD6 homolog A (S cerevisiae) antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human LSM14A
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation. Acts as a repressor of mRNA translation. May play a role in mitotic spindle assembly.
Gene References into Functions
  1. alpha-synuclein p.A53V homozygous mutation leads to a distinct phenotype of progressive parkinsonism and cognitive decline, commonly observed in patients with SNCA missense mutation or multiplications PMID: 28666710
  2. Excessive iron and alpha-synuclein oligomer in brain commonly contributed to pure apathy of PD through potential mechanism of oxidative stress. PMID: 26940028
  3. RAP55/LSM14 binds directly the tubulin and that is implicated in the process of the mitotic spindle stabilization PMID: 26339800
  4. RAP55 is important for the assembly of cytoplasmic mRNP granules and that PRMT1 is required for RAP55A to localize to P-bodies. PMID: 22614839
  5. The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection. PMID: 22973032
  6. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. PMID: 22745163
  7. this protein family has evolved a common and fundamental role in the control of mRNA translation. Human RAP55A is an autoantigen detected in the serum of patients with primary biliary cirrhosis (PBC). PMID: 18723115

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Subcellular Location
Cytoplasm, P-body. Cytoplasm, cytoskeleton, spindle. Cytoplasm, Stress granule.
Protein Families
LSM14 family
Database Links

HGNC: 24489

OMIM: 610677

KEGG: hsa:26065

STRING: 9606.ENSP00000413964

UniGene: Hs.744009

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