LSM14A Antibody

1. alpha-synuclein p.A53V homozygous mutation leads to a distinct phenotype of progressive parkinsonism and cognitive decline, commonly observed in patients with SNCA missense mutation or multiplications PMID: 28666710
2. Excessive iron and alpha-synuclein oligomer in brain commonly contributed to pure apathy of PD through potential mechanism of oxidative stress. PMID: 26940028
3. RAP55/LSM14 binds directly the tubulin and that is implicated in the process of the mitotic spindle stabilization PMID: 26339800
4. RAP55 is important for the assembly of cytoplasmic mRNP granules and that PRMT1 is required for RAP55A to localize to P-bodies. PMID: 22614839
5. The NS1 protein of influenza A virus interacts with cellular processing bodies and stress granules through RNA-associated protein 55 (RAP55) during virus infection. PMID: 22973032
6. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. PMID: 22745163
7. this protein family has evolved a common and fundamental role in the control of mRNA translation. Human RAP55A is an autoantigen detected in the serum of patients with primary biliary cirrhosis (PBC). PMID: 18723115

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HGNC: 24489

OMIM: 610677

KEGG: hsa:26065

STRING: 9606.ENSP00000413964

UniGene: Hs.744009