LYL1 Antibody

1. Despite not being identified as an independent prognostic factor in UCEC, LYL1 gene amplification is associated with other poor prognostic factors and correlated with upregulation of cancer-related pathways. PMID: 29716549
2. In t(8;21) leukemia cells, LYL1 functions as a component of the stable AML1-ETO-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis. PMID: 23812588
3. LYL1 degradation is directed by a N-terminal PEST rich site in a phosphorylation-independent manner. PMID: 20844761
4. LYL1 activity is required for the maturation of newly formed blood vessels in adulthood. PMID: 20418284
5. Over-expression of LYL1 is highly associated with AML as well as ALL. PMID: 19176012
6. Multiple mechanisms which activate LYL1 in leukemic cells, including structural genomic alterations, namely microdeletion or amplification, together with the involvement of prominent oncogenic transcription factors. PMID: 19608273
7. LYL1 may play a role in early hematopoiesis and may be a potential oncogenic factor in AML PMID: 16094422
8. Lyl1 interacts with CREB1 and alters expression of CREB1 target genes. PMID: 18160048

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HGNC: 6734

OMIM: 151440

KEGG: hsa:4066

STRING: 9606.ENSP00000264824

UniGene: Hs.46446