Recombinant Human Protein lyl-1 (LYL1)

Code CSB-YP013258HU
MSDS
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Source Yeast
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Code CSB-EP013258HU
MSDS
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Source E.coli
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Code CSB-EP013258HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP013258HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP013258HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
LYL1
Uniprot No.
Alternative Names
bHLHa18; Class A basic helix-loop-helix protein 18; Lyl1; LYL1_HUMAN; Lymphoblastic leukemia derived sequence 1; Lymphoblastic leukemia-derived sequence 1; lymphoblastomic leukemia 1; Protein lyl 1; Protein lyl-1
Species
Homo sapiens (Human)
Expression Region
1-280
Target Protein Sequence
MCPPQAQAEV GPTMTEKAEM VCAPSPAPAP PPKPASPGPP QVEEVGHRGG SSPPRLPPGV PVISLGHSRP PGVAMPTTEL GTLRPPLLQL STLGTAPPTL ALHYHPHPFL NSVYIGPAGP FSIFPSSRLK RRPSHCELDL AEGHQPQKVA RRVFTNSRER WRQQNVNGAF AELRKLLPTH PPDRKLSKNE VLRLAMKYIG FLVRLLRDQA AALAAGPTPP GPRKRPVHRV PDDGARRGSG RRAEAAARSQ PAPPADPDGS PGGAARPIKM EQTALSPEVR
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Gene References into Functions
  1. Despite not being identified as an independent prognostic factor in UCEC, LYL1 gene amplification is associated with other poor prognostic factors and correlated with upregulation of cancer-related pathways. PMID: 29716549
  2. In t(8;21) leukemia cells, LYL1 functions as a component of the stable AML1-ETO-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis. PMID: 23812588
  3. LYL1 degradation is directed by a N-terminal PEST rich site in a phosphorylation-independent manner. PMID: 20844761
  4. LYL1 activity is required for the maturation of newly formed blood vessels in adulthood. PMID: 20418284
  5. Over-expression of LYL1 is highly associated with AML as well as ALL. PMID: 19176012
  6. Multiple mechanisms which activate LYL1 in leukemic cells, including structural genomic alterations, namely microdeletion or amplification, together with the involvement of prominent oncogenic transcription factors. PMID: 19608273
  7. LYL1 may play a role in early hematopoiesis and may be a potential oncogenic factor in AML PMID: 16094422
  8. Lyl1 interacts with CREB1 and alters expression of CREB1 target genes. PMID: 18160048

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Involvement in disease
A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.
Subcellular Location
Nucleus.
Database Links

HGNC: 6734

OMIM: 151440

KEGG: hsa:4066

STRING: 9606.ENSP00000264824

UniGene: Hs.46446

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