LZTS1 Antibody

Datasheet

Code	CSB-PA013291GA01HU
Size	$600
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Product Details
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Target Background

Product Details

Uniprot No.

Q9Y250

Target Names

LZTS1

Alternative Names

F37 antibody; F37/esophageal cancer related gene coding leucine zipper motif antibody; F37/esophageal cancer-related gene-coding leucine-zipper motif antibody; Fez1 antibody; Leucine zipper putative tumor suppressor 1 antibody; Lzts1 antibody; LZTS1_HUMAN antibody; Psdzip70 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human LZTS1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IF

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor.

Gene References into Functions

missense variant in the LZTS1 gene was identified in two Ehlers-Danlos syndrome patients in an extended family. PMID: 26504261
LZTS1 promoter was frequently methylated in IMPC samples. PMID: 25813822
Compared with the normal hepatocyte cells, LZTS1 expression in hepatocellular carcinoma cells was significantly lower PMID: 26653561
miR-135b expression inversely correlated with LZTS1 staining intensity and the Cutaneous Squamous Cell Carcinoma grade. PMID: 25938461
Suggest that LZTS1 plays a potential tumor suppressor role in colorectal cancer progression and represents a valuable clinical prognostic marker of this disease. PMID: 25667121
Lzts1 was significantly downregulated in breast cancer samples and its deregulation was associated with a higher incidence of tumor recurrence, and to a worse overall survival. PMID: 24448468
miR-214 functions as an onco-miRNA in osteosarcoma, and its oncogenic effects are mediated chiefly through downregulation of LZTS1 PMID: 24802407
Expression of miR-135b, LZTS1, LATS2 and nuclear TAZ predicts poor outcomes of non-small-cell lung cancer. PMID: 23695671
Lower levels of leucine zipper putative tumor suppressor 1 correlated with high histologic grade, lymph node metastasis, and poor prognosis. PMID: 21419475
variation in the germline sequence is associated with prostate cancer risk PMID: 12377406
Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity is associated with oral squamous cell carcinomas PMID: 12851677
Forced expression of LZTS1 in metastasizing uveal melanoma cells inhibited their motility and invasion, whereas depletion of LZTS1 increased their motility. PMID: 18559591
Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast carcinoma involves promoter methylation and associates with metastasis. PMID: 18686028
The reduction or loss of FEZ1 protein could be an aid to the clinical management of patients affected by ovarian carcinoma. PMID: 19885841

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Involvement in disease

Esophageal cancer (ESCR)

Subcellular Location

Cytoplasm. Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density. Cell junction, synapse.

Protein Families

LZTS family

Tissue Specificity

Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many

Database Links

HGNC: 13861

OMIM: 133239

KEGG: hsa:11178

STRING: 9606.ENSP00000265801

UniGene: Hs.521432

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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