Lypla1 Antibody, FITC conjugated

Datasheet

Code	CSB-PA013268LC01MO
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) Lypla1 Polyclonal antibody

Uniprot No.

P97823

Target Names

Lypla1

Alternative Names

Lypla1 antibody; Apt1 antibody; Pla1a antibody; Acyl-protein thioesterase 1 antibody; APT-1 antibody; EC 3.1.2.- antibody; Lysophospholipase 1 antibody; Lysophospholipase I antibody; LPL-I antibody; LysoPLA I antibody

Raised in

Rabbit

Species Reactivity

Mouse

Immunogen

Recombinant Mouse Acyl-protein thioesterase 1 protein (1-230AA)

Immunogen Species

Mus musculus (Mouse)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Acts as a acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Could also depalmitoylate ADRB2. Acts as a lysophospholipase hydrolyzing various lysophospholipids including lysophosphatidylcholine (lyso-PC), lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS)(PubMed:9139730). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA.

Gene References into Functions

Lyplal1 is dispensable for normal mouse metabolic physiology. PMID: 29084768
Data indicate that thioesterases APT1/APT2 depalmitoylate nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) and zDHHC17 is the strongest candidate palmitoyltransferase for NMNAT2. PMID: 25271157
Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43 PMID: 23396970

Subcellular Location

Cytoplasm. Cell membrane. Nucleus membrane. Endoplasmic reticulum.

Protein Families

AB hydrolase superfamily, AB hydrolase 2 family

Database Links

KEGG: mmu:18777

STRING: 10090.ENSMUSP00000027036

UniGene: Mm.299955

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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