MAEA Antibody

Code CSB-PA203871
Size US$297
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  • Western blot analysis of extracts from COLO205 cells, using MAEA antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MAEA Polyclonal antibody
Uniprot No.
Target Names
MAEA
Alternative Names
1110030D19Rik antibody; Cell proliferation inducing gene 5 protein antibody; Cell proliferation-inducing gene 5 protein antibody; EMLP antibody; EMP antibody; Erythroblast macrophage protein antibody; GID complex subunit 9 FYV10 homolog antibody; GID9 antibody; HLC 10 antibody; HLC-10 antibody; HLC10 antibody; Human lung cancer oncogene 10 protein antibody; Lung cancer related protein 10 antibody; Macrophage erythroblast attacher antibody; MAEA antibody; MAEA_HUMAN antibody; MGC93683 antibody; PIG5 antibody; Proliferation inducing gene 5 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from internal of Human MAEA.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages. Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events (Probable).
Gene References into Functions
  1. Emp expression correlates with erythroblastic island formation and has an important function for bone marrow hematopoiesis. PMID: 23566571
  2. These results suggest that Emp undergoes dynamic rearrangements within the nuclear architecture that are correlated with cell division. PMID: 16510120
  3. RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and p44CTLH form complexes in cells. PMID: 17467196
Subcellular Location
Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton.
Tissue Specificity
Detected at macrophage membranes (at protein level). Ubiquitous.
Database Links

HGNC: 13731

OMIM: 606801

KEGG: hsa:10296

STRING: 9606.ENSP00000302830

UniGene: Hs.139896

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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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