MAFF Antibody

Code CSB-PA008439
Size US$100
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Product Details

Uniprot No.
Target Names
MAFF
Alternative Names
Avian musculoaponeurotic fibrosarcoma virus (v maf) AS42 oncogene, protein F antibody; CTA 447C4.1 antibody; hMafF antibody; MAFF antibody; MAFF_HUMAN antibody; OTTHUMP00000199299 antibody; Transcription factor MafF antibody; U MAF antibody; U-Maf antibody; V maf avian musculoaponeurotic fibrosarcoma oncogene family, protein F antibody; V maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) antibody; V maf musculoaponeurotic fibrosarcoma oncogene homolog F antibody; V-maf musculoaponeurotic fibrosarcoma oncogene homolog F antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from the Internal region of Human MafF.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition.
Gene References into Functions
  1. MAF genes have different levels of biological and genetic relevance. Besides, MAFF and MAFG could be associated with the susceptibility to develop CML. PMID: 24118457
  2. MafF/NFE2 hetrodimers act as weak transcriptional activators, and, in particular, are able to stimulate activity of the GCS1 promoter. PMID: 12490281
  3. In myometrial cells we observed an important induction by interleukin 1 beta and a weaker upregulation by tumor necrosis factor, whereas interleukin 6 treatment had no effect. PMID: 16371591
  4. Expression of hMafF or MIP alone did not alter basal reporter transcription activity, whereas co-expression of hMafF and MIP activated transcription efficiently. PMID: 16549056
  5. Only in the presence of both MIP and hMafF could the nUS2-pLacZi reporter in yeast genome be activated. PMID: 19723544

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Subcellular Location
Nucleus.
Protein Families
BZIP family, Maf subfamily
Tissue Specificity
Expressed in the term myometrium and kidney.
Database Links

HGNC: 6780

OMIM: 604877

KEGG: hsa:23764

STRING: 9606.ENSP00000345393

UniGene: Hs.517617

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