MAGEB2 Antibody

Code CSB-PA013342GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
MAGEB2
Alternative Names
MAGEB2Melanoma-associated antigen B2 antibody; Cancer/testis antigen 3.2 antibody; CT3.2 antibody; DSS-AHC critical interval MAGE superfamily 6 antibody; DAM6 antibody; MAGE XP-2 antigen antibody; MAGE-B2 antigen antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Human MAGEB2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
Gene References into Functions
  1. MAGEB2 can be aberrantly demethylated and expressed in malignant peripheral nerve sheath tumors. Conversely, the gene may not be demethylated in any types of neurofibroma, suggesting that the demethylation does not occur before malignant transformation. PMID: 26642794
  2. MageB2 counteracts E2F inhibition by ribosomal proteins independently of Mdm2 expression PMID: 26468294
  3. we identified MAGEB2 as activated by promoter demethylation in HNSCCand demonstrates growth promoting effects in a minimally transformed oral keratinocyte cell line. PMID: 23029077
  4. Valproic acid causes a change in acetylation of this gene. PMID: 17012225
Tissue Specificity
Expressed in testis and placenta, and in a significant fraction of tumors of various histologic types.
Database Links

HGNC: 6809

OMIM: 300098

KEGG: hsa:4113

STRING: 9606.ENSP00000368273

UniGene: Hs.113824

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