MAML2 Antibody, FITC conjugated

Datasheet
Code CSB-PA809028LC01HU
Size US$299
Uniprot No. Q8IZL2
Immunogen Recombinant Human Mastermind-like protein 2 protein (347-506AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Mastermind-like protein 2 (Mam-2), MAML2, KIAA1819
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Epigenetics and Nuclear Signaling
Target Names MAML2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.
Involvement in disease A chromosomal aberration involving MAML2 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with CRTC1. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.
Subcellular Location Nucleus speckle
Protein Families Mastermind family
Tissue Specificity Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle.
Database Links

HGNC: 16259

OMIM: 607537

KEGG: hsa:84441

STRING: 9606.ENSP00000412394

UniGene: Hs.371096

Pathway Notch signaling pathway
Th1 and Th2 cell differentiation

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