MAML2 Antibody

Datasheet
Code CSB-PA809028LA01HU
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Size US$299
Uniprot No. Q8IZL2
Image
  • Western Blot
    Positive WB detected in: Hela whole cell lysate, SH-SY5Y whole cell lysate, A549 whole cell lysate, PC-3 whole cell lysate, COLO320 whole cell lysate
    All lanes: MAML2 antibody at 2.2μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 126 kDa
    Observed band size: 126 kDa

  • IHC image of CSB-PA809028LA01HU diluted at 1:800 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA809028LA01HU diluted at 1:800 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunogen Recombinant Human Mastermind-like protein 2 protein (347-506AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000
Relevance Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Mastermind-like protein 2 (Mam-2), MAML2, KIAA1819
Immunogen Species Human
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Research Area Epigenetics and Nuclear Signaling
Target Names MAML2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3.
Involvement in disease A chromosomal aberration involving MAML2 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with CRTC1. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.
Subcellular Location Nucleus speckle
Protein Families Mastermind family
Tissue Specificity Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle.
Database Links

HGNC: 16259

OMIM: 607537

KEGG: hsa:84441

STRING: 9606.ENSP00000412394

UniGene: Hs.371096

Pathway Notch signaling pathway
Th1 and Th2 cell differentiation

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