MAP1A Antibody

Datasheet

Code	CSB-PA013400LA01HU
Size	US$166
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Image	IHC image of CSB-PA013400LA01HU diluted at 1:400 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA013400LA01HU diluted at 1:400 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. Immunofluorescence staining of HepG2 cells with CSB-PA013400LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MAP1A Polyclonal antibody

Uniprot No.

P78559

Target Names

MAP1A

Alternative Names

MAP 1A antibody; MAP 1L antibody; MAP-1A antibody; MAP1 light chain LC2 antibody; Map1a antibody; MAP1A_HUMAN antibody; MAP1L antibody; Microtubule associated protein 1 like antibody; Microtubule associated protein 1A antibody; MTAP 1A antibody; MTAP1A antibody; Proliferation related protein p80 antibody; Proliferation-related protein p80 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Microtubule-associated protein 1A protein (1979-2168AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MAP1A Antibody (Product code: CSB-PA013400LA01HU) is Non-conjugated. For MAP1A Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA013400LB01HU	MAP1A Antibody, HRP conjugated	ELISA
FITC	CSB-PA013400LC01HU	MAP1A Antibody, FITC conjugated
Biotin	CSB-PA013400LD01HU	MAP1A Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.

Gene References into Functions

MAP1A functions to maintain the neuronal microtubule network in the brain and mutations cause Purkinje cell degeneration. PMID: 25788676
results support a role for MAP1 proteins in promoting efficient retrograde trafficking of HIV-1 by stimulating the formation of stable microtubules and mediating the association of HIV-1 cores with microtubules. PMID: 25505242
This protein has been found differentially expressed in thalami from patients with schizophrenia. PMID: 20471030
Data show that two regulatory factor for X box (RFX1 and 3) binding sites in exon1 of both the mouse and human microtubule-associated protein (MAP1A) gene are important for effective transcriptional repression in non-neuronal cells. PMID: 12411430
a novel protein-binding partner for EPAC1 and EPAC2, light chain 2 of MAP1A (microtubule-associated protein 1A) PMID: 15202935
MAP1A LC2 is a biological enhancer of EPAC1 activity toward Rap1 and associated downstream signaling mechanisms PMID: 15591041
Complexes (MAP1B heavy chain-MAP1A light chain) form through interaction of homologous domains conserved in heavy and light chains of MAP1A and MAP1B. Conserved domains of the MAP1A and MAP1B light chains account for formation of light chain heterodimers. PMID: 16996626
postulate that the RhoB and MAP1A/LC2 interactions facilitate endocytic vesicle trafficking and regulate the trafficking of signaling molecules PMID: 18056259

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Subcellular Location

Cytoplasm, cytoskeleton.

Protein Families

MAP1 family

Tissue Specificity

Brain.

Database Links

HGNC: 6835

OMIM: 600178

KEGG: hsa:4130

STRING: 9606.ENSP00000300231

UniGene: Hs.194301

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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