MAP1A Antibody, Biotin conjugated

1. MAP1A functions to maintain the neuronal microtubule network in the brain and mutations cause Purkinje cell degeneration. PMID: 25788676
2. results support a role for MAP1 proteins in promoting efficient retrograde trafficking of HIV-1 by stimulating the formation of stable microtubules and mediating the association of HIV-1 cores with microtubules. PMID: 25505242
3. This protein has been found differentially expressed in thalami from patients with schizophrenia. PMID: 20471030
4. Data show that two regulatory factor for X box (RFX1 and 3) binding sites in exon1 of both the mouse and human microtubule-associated protein (MAP1A) gene are important for effective transcriptional repression in non-neuronal cells. PMID: 12411430
5. a novel protein-binding partner for EPAC1 and EPAC2, light chain 2 of MAP1A (microtubule-associated protein 1A) PMID: 15202935
6. MAP1A LC2 is a biological enhancer of EPAC1 activity toward Rap1 and associated downstream signaling mechanisms PMID: 15591041
7. Complexes (MAP1B heavy chain-MAP1A light chain) form through interaction of homologous domains conserved in heavy and light chains of MAP1A and MAP1B. Conserved domains of the MAP1A and MAP1B light chains account for formation of light chain heterodimers. PMID: 16996626
8. postulate that the RhoB and MAP1A/LC2 interactions facilitate endocytic vesicle trafficking and regulate the trafficking of signaling molecules PMID: 18056259

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HGNC: 6835

OMIM: 600178

KEGG: hsa:4130

STRING: 9606.ENSP00000300231

UniGene: Hs.194301