MAP3K10 Antibody

Code CSB-PA010199
Size US$100
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Product Details

Uniprot No.
Target Names
Alternative Names
M3K10_HUMAN antibody; MAP3K 10 antibody; Map3k10 antibody; MEKK10 antibody; Mitogen activated protein kinase kinase kinase 10 antibody; Mitogen-activated protein kinase kinase kinase 10 antibody; Mixed lineage kinase 2 antibody; MKN28 derived nonreceptor type serine/threonine kinase antibody; MKN28 kinase antibody; MLK 2 antibody; MST antibody; Protein kinase MST antibody
Raised in
Species Reactivity
Synthesized peptide derived from the Internal region of Human MLK2.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:20000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Activates the JUN N-terminal pathway.
Gene References into Functions
  1. MST interaction with MOB1 is not essential for development and tissue growth control. PMID: 28947795
  2. We identified a direct target of miR-155 as MAP3K10 in osteosarcoma PMID: 28214207
  3. A novel and important role for MAP3K10 in the proliferation and chemoresistance of pancreatic ductal adenocarcinoma. PMID: 23178452
  4. This study showed that show that RUNX3 is a principal and evolutionarily conserved component of the MST pathway. PMID: 21678419
  5. Mechanism of MAP kinase activation by TNF requires Src-dependent activation of Vav, activation of Rac/Cdc42, and the engagement of the Rac/Cdc42 interaction site on MLK3. PMID: 21979919
  6. Mechanism of MAP kinase activation by TNF requires Src-dependent activation of Vav, activation of Rac/Cdc42, and the engagement of the Rac/Cdc42 interaction site on MLK2 and 3. PMID: 21979919
  7. Data show that miR-181b contributed to proliferation of AML cells by targeting MLK2. PMID: 20596961
  8. MLK2 has a role in vesicle formation and endosome recycling by binding to clathrin PMID: 12105200
  9. demonstrate Alien-MLK2 interaction and also show that MLK2 is able to phosphorylate Alien; Alien, DAX-1 and thyroid hormone receptor mediated transcriptional silencing is strongly enhanced in the presence of active MLK2 PMID: 15062575
  10. MLK2 and -3 are required for activation of JNK and p38 by ectopically expressed GCK PMID: 17584736
  11. Hippocalcin and MLK2 were colocalized in the halo of Lewy bodies in Parkinson disease patients, and neither protein was detected in normal pigmented neurons. PMID: 19332348
  12. Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways PMID: 19801649

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Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
Tissue Specificity
Expressed in brain and skeletal muscle.
Database Links

HGNC: 6849

OMIM: 600137

KEGG: hsa:4294

STRING: 9606.ENSP00000253055

UniGene: Hs.466743

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