MAP3K10 Antibody

1. MST interaction with MOB1 is not essential for development and tissue growth control. PMID: 28947795
2. We identified a direct target of miR-155 as MAP3K10 in osteosarcoma PMID: 28214207
3. A novel and important role for MAP3K10 in the proliferation and chemoresistance of pancreatic ductal adenocarcinoma. PMID: 23178452
4. This study showed that show that RUNX3 is a principal and evolutionarily conserved component of the MST pathway. PMID: 21678419
5. Mechanism of MAP kinase activation by TNF requires Src-dependent activation of Vav, activation of Rac/Cdc42, and the engagement of the Rac/Cdc42 interaction site on MLK3. PMID: 21979919
6. Mechanism of MAP kinase activation by TNF requires Src-dependent activation of Vav, activation of Rac/Cdc42, and the engagement of the Rac/Cdc42 interaction site on MLK2 and 3. PMID: 21979919
7. Data show that miR-181b contributed to proliferation of AML cells by targeting MLK2. PMID: 20596961
8. MLK2 has a role in vesicle formation and endosome recycling by binding to clathrin PMID: 12105200
9. demonstrate Alien-MLK2 interaction and also show that MLK2 is able to phosphorylate Alien; Alien, DAX-1 and thyroid hormone receptor mediated transcriptional silencing is strongly enhanced in the presence of active MLK2 PMID: 15062575
10. MLK2 and -3 are required for activation of JNK and p38 by ectopically expressed GCK PMID: 17584736
11. Hippocalcin and MLK2 were colocalized in the halo of Lewy bodies in Parkinson disease patients, and neither protein was detected in normal pigmented neurons. PMID: 19332348
12. Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways PMID: 19801649

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HGNC: 6849

OMIM: 600137

KEGG: hsa:4294

STRING: 9606.ENSP00000253055

UniGene: Hs.466743