MAP3K4 Antibody

Code CSB-PA013426GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4) antibody; FLJ42439 antibody; KIAA0213 antibody; M3K4_HUMAN antibody; MAP three kinase 1 antibody; MAP/ERK kinase kinase 4 antibody; MAP3K4 antibody; MAPK/ERK kinase kinase 4 antibody; MAPKKK4 antibody; MEK kinase 4 antibody; MEKK 4 antibody; MEKK4 antibody; Mitogen-activated protein kinase kinase kinase 4 antibody; MTK1 antibody; predicted protein of HQ0412 antibody; PRO0412 antibody; RP3-473J16.4 antibody; SSK2/SSK22 MAP kinase kinase kinase; yeast; homolog of antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human MAP3K4
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
Gene References into Functions
  1. IL-21 expression is promoted by MEKK4 in malignant T cells and is associated with progression risk in cutaneous T-cell lymphoma PMID: 26802931
  2. Mutations in genes such as AKT2, CCNA1, MAP3K4, and TGFBR1, were associated significantly with Epstein-Barr-positive gastric tumors, compared with EBV-negative tumors. PMID: 25173755
  3. Map3k4 haploinsufficiency is the cause of T-associated sex reversal. PMID: 24452333
  4. MTK1 was identified in the HER2/HER3-HRG mediated extracellular acidification and cell migration pathway in breast cancer cells. PMID: 24036211
  5. MAP3K4 is sufficiently mediate the TGFbeta-induced phosphorylation of p38 MAPK in MEFs and HaCaT cells. PMID: 23760366
  6. we have identified a reduced IL-1A response, related to a low MAP3K4 expression and high expression of its inhibitor GSK3beta, identifying a novel key player in Crohn's disease. PMID: 22732089
  7. For the first time we report a significant association between nicotine dependence and DRD5, NPY1R MAP3K4 single nucleotide polymorphism. PMID: 22309839
  8. CIN85 binding to a C-terminal motif within hTTP leads to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4 PMID: 20221403
  9. MEKK4 is the MAPK kinase kinase for TRAF4 regulation of the JNK pathway PMID: 16157600
  10. Taken together, these results indicate a novel role for CIN85 in the regulation of cellular stress response via the MAPK pathways. PMID: 16256071
  11. In this review, the role of MKK4 in cancer development appears complex, as some studies support a pro-oncogenic role for MKK4, while others suggest it may have tumor suppressor functions. PMID: 17496914

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Subcellular Location
Cytoplasm, perinuclear region.
Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
Tissue Specificity
Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.
Database Links

HGNC: 6856

OMIM: 602425

KEGG: hsa:4216

STRING: 9606.ENSP00000375986

UniGene: Hs.390428

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