MAP4K1 Antibody

1. Interactions between HPK1 and its adaptor proteins related to immunity has been discussed (Review). PMID: 28901492
2. HPK1 protein expression, which is expressed at significantly higher levels in NATs compared with paired IDC-NOS tissues, is significantly negatively associated with ER positivity and is positively associated with OS duration, suggesting that HPK1 may exhibit anticancer activities. PMID: 28765906
3. CUL7/Fbxw8 ubiquitin ligase-mediated HPK1 degradation revealed a direct link and novel role of CUL7/Fbxw8 ubiquitin ligase in the MAPK pathway, which plays a critical role in cell proliferation and differentiation. PMID: 24362026
4. HPK1 is critically involved in LFA-1-mediated polymorphonuclear neutrophils trafficking during acute inflammation. PMID: 23460610
5. results indicate that uncleaved HPK1 is a positive regulator of vitamin D-induced differentiation in acute myeloid leukemia cells, but the cleaved HPK1 fragment inhibits differentiation PMID: 22421156
6. Pdcd4 knockdown up-regulates MAP kinase kinase kinase kinase 1 (MAP4K1) expression and increases phosphorylation of c-Jun. PMID: 22801218
7. QVD and 1,25D-induced differentiation was accompanied by increased signaling by Hematopoietic Progenitor Kinase 1(HPK1), and the expression of transcription factors known to be involved in monocytic differentiation was increased. PMID: 22541691
8. HPK1 negatively regulates T cell activation by reducing the persistence of signaling microclusters. PMID: 22105350
9. The purpose of the study was to investigate the potential contribution of HPK1, MEKK1, TAK1, p-MKK4 to the development of extramammary Paget disease PMID: 21915030
10. The catalytic activity of a hematopoietic cell-restricted, Ste20-related S/TPK, HPK1, is positively regulated by exposure to physiological concentrations of PGE2. HPK1 is a negative regulator of PGE2-induced FOS gene transcription. PMID: 12522005
11. PP4 is a positive regulator for HPK1 and the HPK1-JNK signaling pathway PMID: 15364934
12. Full activation of HPK1 is dependent on autophosphorylation of threonine 165 and phosphorylation of serine 171, which is a target site for protein kinase D (PKD) in vitro. PMID: 15743830
13. suppression or activation of NFkappaB by HPK1 determines sensitivity to activation-induced cell death PMID: 16341093
14. Pdcd4 suppresses tumor progression in colon carcinoma cells by the novel mechanism of down-regulating MAP4K1 transcription, with consequent inhibition of c-Jun activation and AP-1-dependent transcription. PMID: 16449643
15. Our work explains growth factor-independent survival during monocytic differentiation by caspase-mediated processing of HPK1 towards HPK1-N. PMID: 17024227
16. A novel negative feedback loop involves HPK-1-dependent serine phosphorylation of SLP-76 and 14-3-3 protein recruitment, which tunes T cell activation. PMID: 17353368
17. HPK1-C as a suppressor of antiapoptotic Bcl-2 proteins and provide a molecular basis for our understanding of CD95L-independent activation-induced cell death of lymphocytes. PMID: 17712048
18. Prostaglandin E2 activates HPK1 kinase activity via a PKA-dependent pathway PMID: 17895239
19. Restoring wild-type HPK1 protein in pancreatic cancer cells led to the increase in p21 and p27 protein expression and cell cycle arrest. HPK1 may function as a novel tumor suppressor and its loss plays a critical role in pancreatic cancer. PMID: 19141650
20. Results suggest HPK1-mediated phosphorylation of CARMA1 as an additional regulatory mechanism tuning the NF-kappaB response upon TCR stimulation. PMID: 19706536

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HGNC: 6863

OMIM: 601983

KEGG: hsa:11184

STRING: 9606.ENSP00000380066

UniGene: Hs.95424