MAP4K3 Antibody

1. hepatocellular carcinoma recurrence may involve germinal center kinase-like kinase PMID: 27343552
2. Data indicate that GLK/MAP4K3 is a prognostic biomarker for non-small cell lung cancer (NSCLC) recurrence. PMID: 27203390
3. Authors report that miR-199a-5p and let-7c cooperatively and efficiently inhibit HCC cell migration and invasion by targeting the metastasis promoter MAP4K3 and MAP4K3-mediated drug sensitization. PMID: 28099144
4. This report details the first structure of GLK; comparison of its activation loop sequence and P-loop structure to that of Map4k4 suggests ideas for designing inhibitors that can distinguish between these family members to achieve selective pharmacological inhibitors. PMID: 27727493
5. ITGB3 and MAP4K3 are directly repressed by let-7c, altering the metastatic potential of lung cancer cells. PMID: 23981581
6. MAP4K3 expression is required for leucine-induced mTORC1 activation in human primary fibroblasts. PMID: 22898570
7. Significantly higher median frequencies of circulating GLK-expressing T-cells were observed in patients with adult-onset Still's disease (31.85%) than in healthy volunteers (8.93%, P <0.001). PMID: 22867055
8. enhanced expression in systemic lupus erythematosus PMID: 21983831
9. Amino acid sufficiency phosphorylates MAP4K3/Ser170, activating mTORC1, but amino acid restriction causes MAP4K3 to interact with PP2A(T61 epsilon), promoting dephosphorylation of Ser170, MAP4K3 inhibition, and, inhibition of mTORC1 signaling. PMID: 20227368
10. MAP4K3 orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM. PMID: 19587239

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HGNC: 6865

OMIM: 604921

KEGG: hsa:8491

STRING: 9606.ENSP00000263881

UniGene: Hs.655750