MCF2 Antibody, Biotin conjugated

Code CSB-PA013579LD01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) MCF2 Polyclonal antibody
Uniprot No. P10911
Target Names MCF2
Alternative Names MCF2 antibody; DBLProto-oncogene DBL antibody; Proto-oncogene MCF-2) [Cleaved into: MCF2-transforming protein; DBL-transforming protein] antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Proto-oncogene DBL protein (705-925AA)
Immunogen Species Homo sapiens (Human)
Conjugate Biotin
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.
Gene References into Functions
  1. Results support a role for Dbl oncogene in mammary epithelial cell differentiation and transformation and suggest the relevance of GEF deregulation in tumor onset and progression. PMID: 25723869
  2. Phosphoinositide 3-kinase C2beta regulates RhoA and the actin cytoskeleton through an interaction with Dbl PMID: 22984590
  3. Dbl is regulated by hamartin through association with ezrin. PMID: 21712385
  4. proto-oncogene dbl is not a major target for sporadic testicular germ cell tumors PMID: 19373475
  5. data describe 4 splicing variants of the human DBL (MCF-2) proto-oncogene that show different tissue distributions and guanine nucleotide exchange factor specificities PMID: 12445822
  6. provides fundamental data on the structure of Mcf-2, which regulates a variety of cellular signaling pathways PMID: 13679059
  7. These data suggest a mechanism whereby precise spatial guanine nucleotide exchange of Cdc42 by Dbl is dependent on functional ERM proteins and is important for directional cell migration. PMID: 17538024
  8. Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain PMID: 17606614
  9. Nm23-H1 can negatively regulate cell migration and tumor metastasis by modulating the activity of Cdc42 and possibly other Rho family members through interaction with Dbl-1 PMID: 18728402

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Involvement in disease MCF2 and DBL represent two activated versions of the same proto-oncogene.
Subcellular Location Cytoplasm, SUBCELLULAR LOCATION: Isoform 1: Membrane, SUBCELLULAR LOCATION: Isoform 3: Membrane
Protein Families MCF2 family
Tissue Specificity Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, int
Database Links

HGNC: 6940

OMIM: 311030

KEGG: hsa:4168

STRING: 9606.ENSP00000430276

UniGene: Hs.387262

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