MEGF10 Antibody

Datasheet

Code	CSB-PA822242LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA822242LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA822242LA01HU at dilution of 1:100 Immunofluorescent analysis of HepG2 cells using CSB-PA822242LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MEGF10 Polyclonal antibody

Uniprot No.

Q96KG7

Target Names

MEGF10

Alternative Names

MEGF10 antibody; KIAA1780Multiple epidermal growth factor-like domains protein 10 antibody; Multiple EGF-like domains protein 10 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Multiple epidermal growth factor-like domains protein 10 protein (123-314AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The MEGF10 Antibody (Product code: CSB-PA822242LA01HU) is Non-conjugated. For MEGF10 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA822242LB01HU	MEGF10 Antibody, HRP conjugated	ELISA
FITC	CSB-PA822242LC01HU	MEGF10 Antibody, FITC conjugated
Biotin	CSB-PA822242LD01HU	MEGF10 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum. Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements.

Gene References into Functions

Results suggested that methylation level and mRNA expression of MEGF10 in glioma were not only correlated with IDH mutation but also associated with clinical outcome of patients. PMID: 29887919
Concentrating on hypermethylated genes to identify candidate tumor suppressor loci, the study found the cell engulfment and adhesion factor gene MEGF10 to be epigenetically repressed by DNA hypermethylation or by H3K27/K9 methylation in neuroblastoma cell lines. PMID: 27862318
MEGF10 mutations can cause myopathy with adult-onset respiratory insufficiency PMID: 26802438
results indicate that myogenin is a positive regulator in transcriptional regulation of MEGF10 in skeletal muscle PMID: 25044114
Megf10 is required for preserving the undifferentiated, proliferative potential of satellite cells, myogenic precursors that regenerate skeletal muscle in response to injury or disease. PMID: 22371254
Mutations in MEGF10 cause a recessive congenital myopathy with minicores and suggest satellite cell dysfunction as the pathogenic mechanism PMID: 22371254
Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD) PMID: 22101682
The results of this study suggested that no association between schizophrenia and rs27388 of the MEGF10 gene in Chinese case-control sample. PMID: 20813413
MEGF10 is involved in the uptake of amyloid-beta peptide (Abeta42) in the brain. PMID: 20828568
in a system of forced expression by transfection, MEGF10 function can be modulated by the ATP binding cassette transporter ABCA1, ortholog to CED-7 PMID: 17205124
Human MEGF10 is an ortholog of Ced1. PMID: 17498693
An interaction between MEGF10 and clathrin assembly protein complex 2 medium chain (AP50), a component of clathrin-coated pits was identified. PMID: 17643423
In expression studies, MEGF10 had higher expression levels in the affected than the unaffected (p = .015). Schizophrenia patients with a 1/1 genotype at rs27388 had higher expressions than those patients with 1/2 and 2/2 genotypes (p = .0008). PMID: 18179784

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Involvement in disease

Myopathy, early-onset, areflexia, respiratory distress, and dysphagia (EMARDD)

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell projection, phagocytic cup.

Protein Families

MEGF family

Database Links

HGNC: 29634

OMIM: 612453

KEGG: hsa:84466

STRING: 9606.ENSP00000274473

UniGene: Hs.438709

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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