MEGF10 Antibody, FITC conjugated

1. Results suggested that methylation level and mRNA expression of MEGF10 in glioma were not only correlated with IDH mutation but also associated with clinical outcome of patients. PMID: 29887919
2. Concentrating on hypermethylated genes to identify candidate tumor suppressor loci, the study found the cell engulfment and adhesion factor gene MEGF10 to be epigenetically repressed by DNA hypermethylation or by H3K27/K9 methylation in neuroblastoma cell lines. PMID: 27862318
3. MEGF10 mutations can cause myopathy with adult-onset respiratory insufficiency PMID: 26802438
4. results indicate that myogenin is a positive regulator in transcriptional regulation of MEGF10 in skeletal muscle PMID: 25044114
5. Megf10 is required for preserving the undifferentiated, proliferative potential of satellite cells, myogenic precursors that regenerate skeletal muscle in response to injury or disease. PMID: 22371254
6. Mutations in MEGF10 cause a recessive congenital myopathy with minicores and suggest satellite cell dysfunction as the pathogenic mechanism PMID: 22371254
7. Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD) PMID: 22101682
8. The results of this study suggested that no association between schizophrenia and rs27388 of the MEGF10 gene in Chinese case-control sample. PMID: 20813413
9. MEGF10 is involved in the uptake of amyloid-beta peptide (Abeta42) in the brain. PMID: 20828568
10. in a system of forced expression by transfection, MEGF10 function can be modulated by the ATP binding cassette transporter ABCA1, ortholog to CED-7 PMID: 17205124
11. Human MEGF10 is an ortholog of Ced1. PMID: 17498693
12. An interaction between MEGF10 and clathrin assembly protein complex 2 medium chain (AP50), a component of clathrin-coated pits was identified. PMID: 17643423
13. In expression studies, MEGF10 had higher expression levels in the affected than the unaffected (p = .015). Schizophrenia patients with a 1/1 genotype at rs27388 had higher expressions than those patients with 1/2 and 2/2 genotypes (p = .0008). PMID: 18179784

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HGNC: 29634

OMIM: 612453

KEGG: hsa:84466

STRING: 9606.ENSP00000274473

UniGene: Hs.438709