MEPE Antibody

Code CSB-PA013704GA01HU
Size US$685
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Product Details

Uniprot No. Q9NQ76
Target Names MEPE
Alternative Names Matrix extracellular phosphoglycoprotein antibody; MEPE antibody; MEPE_HUMAN antibody; OF45 antibody; Osteoblast/osteocyte factor 45 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Human MEPE
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Promotes renal phosphate excretion and modulates mineralization.
Gene References into Functions
  1. Results indicate an association of MEPE gene inactivation with decreased survival after DNA damage. PMID: 23570370
  2. Mice deficient in an ortholog of MEPE show increased bone mass and are resistant to aging-related bone loss. PMID: 12421822
  3. results indicated that MEPE appeared to play an important positive role in proliferation and osteogenesis differentiation of DPCs through interaction with downstream signals. PMID: 22341070
  4. MEPE or the MEPE-derived acidic serine aspartate-rich MEPE-associated motif peptide may contribute to decreased bone mineralization in Oncogenic osteomalacia patients. PMID: 21739089
  5. Among migraineurs with aura rs7698623 in MEPE (OR = 6.37; 95% CI 3.15-12.90; p = 2.7x10(-7)) and rs4975709 in IRX4 (OR = 5.06; 95% CI 2.66-9.62; p = 7.7x10(-7)) appeared to be associated with ischemic stroke. PMID: 21779381
  6. Sclerostin acts through regulation of the PHEX/MEPE axis at the preosteocyte stage and serves as a master regulator of physiologic bone mineralization. PMID: 21312267
  7. MEPE may play a regulatory role in periodontal ligament cell osteogenic differentiation. PMID: 19031789
  8. These results suggest that abnormal MEPE cleavage occurs when PHEX activity is deficient in humans. PMID: 20581062
  9. This study demonstrates the importance of posttranslational modification for the site-specific activity of MEPE and its ASARM peptide. PMID: 19998030
  10. The patterns of expression of FGF-23, MEPE, and DMP1 differ markedly in trabecular bone, suggesting that individual osteocytes may have specialized functions. PMID: 19679205
  11. MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21. Expressed during odontogenesis. PMID: 12489176
  12. There is evidence for a hormone/enzyme/extracellular matrix protein cascade involving fibroblastic growth factor 23 (FGF23), a phosphate-regulating gene with homologies to (PHEX) and (MEPE)--REVIEW PMID: 12791601
  13. MEPE is predominantly expressed by osteocytes in human bone, with significant expression by osteocytes within mineralized bone PMID: 15108058
  14. The results are consistent with MEPE being involved in phosphate and bone metabolism in a normal population. PMID: 15292364
  15. MEPE expression is higher when cells proliferate, whereas it is downregulated as cells differentiated PMID: 18547474
  16. MEPE is a candidate phosphatonin involved in phosphate homeostasis, acting in both the kidney and the gastrointestinal tract PMID: 19005008
  17. MEPE is expressed in salivary gland ducts. PMID: 15329369
  18. MEPE is expressed on the luminal surface of kidney proximal tubules. PMID: 15954904

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Subcellular Location Secreted, extracellular space, extracellular matrix
Tissue Specificity Expressed by osteoblasts. Secreted from oncogenic hypophosphataemic tumors.
Database Links

HGNC: 13361

OMIM: 605912

KEGG: hsa:56955

STRING: 9606.ENSP00000354341

UniGene: Hs.676357


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