MGAT3 Antibody, FITC conjugated

1. Novel insights into the epigenetic regulation of MGAT3/bisecting GlcNAc and demonstrate the importance of N-glycosylation in cancer progression. PMID: 27429195
2. Data suggest that GNT-III expression regulates levels/activation of the heavily glycosylated Notch receptor involved in normal and malignant cell development; suppression of GNT-III in epithelial ovarian carcinoma cell lines results in down-regulation of Notch signaling that is more potent than pharmacologic blockage of Notch activation. PMID: 28842505
3. MGAT3 expressed in cells stimulates lipid droplet growth. These findings provide additional evidence that MGAT3 likely functions as a triacylglycerol synthase in cells. PMID: 27184406
4. Core-fucosylated tetra-antennary structures were decreased in quantity likely as a result of hypomethylated MGAT3 gene promoter followed by increased expression of this gene PMID: 27073020
5. High expression of alpha2,6-sialylation on the cell surface could affect the anti-migratory role of GnT-III, which provides an insight into the mechanistic roles of GnT-III in tumor metastasis. PMID: 26801611
6. Mgat3 plays an important role in early spontaneous miscarriage in humans. PMID: 26109616
7. MGAT3 protein and gene expression in in uveal and cutaneous melanoma cells PMID: 26098720
8. HS5 cells had significantly enhanced levels of bisecting N-glycans (catalyzed by MGAT3 whereas HS27a cells had enhanced levels of Galbeta1,4GlcNAc. PMID: 25936519
9. GnT-III determines E-cadherin-mediated tumor suppression, and GnT-V regulates E-cadherin-mediated tumor invasion. PMID: 23671930
10. Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor beta1 (TGF-beta1) in epithelial cell lines PMID: 22451656
11. MGAT3 mRNA biomarker may characterize subgroups of Alzheimer's disease patients with different disease progression. PMID: 21368380
12. the modulation of glycosyltransferases MGAT3 and MGAT5 by synthetic N-acetyl-D-glucosamine-calix[4]arene correlated with the improvement of NK cell effector functions and the augmentation of tumor cells sensitivity to NK cell-mediated cytotoxicity. PMID: 20089585
13. upregulation of GnT-III in AD brains may represent an adaptive response to protect them from additional beta-amyloid production PMID: 19776078
14. down-regulation of hydrogen peroxide-induced PKC delta activation in cells transfected with this enzyme PMID: 12427758
15. MGAT3 and MGAT5 competitively modified E-cadherin N-glycans. PMID: 19403558

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HGNC: 7046

OMIM: 604621

KEGG: hsa:4248

STRING: 9606.ENSP00000345270

UniGene: Hs.276808