MGAT3 Antibody, HRP conjugated

Code CSB-PA22969B0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MGAT3 Polyclonal antibody
Uniprot No.
Target Names
MGAT3
Alternative Names
4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase antibody; Beta 1 4 mannosyl glycoprotein 4 beta N acetylglucosaminyltransferase antibody; Beta-1 antibody; FLJ43371 antibody; GlcNAc T III antibody; GlcNAc-T III antibody; GNT 3 antibody; GNT III antibody; GNT-III antibody; GNT3 antibody; Mannosyl (beta 1 4 ) glycoprotein beta 1 4 N acetylglucosaminyltransferase antibody; MGAT 3 antibody; MGAT3 antibody; MGAT3_HUMAN antibody; MGC141943 antibody; MGC142278 antibody; N acetylglucosaminyltransferase III antibody; N glycosyl oligosaccharide glycoprotein N acetylglucosaminyltransferase III antibody; N-acetylglucosaminyltransferase III antibody; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III antibody; OTTHUMP00000042207 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase protein (435-533AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition, but also the conformation of the N-glycan. The introduction of the bisecting GlcNAc residue results in the suppression of further processing and elongation of N-glycans, precluding the formation of beta-1,6 GlcNAc branching, catalyzed by MGAT5 since it is unable to use the bisected oligosaccharide as a substrate. Addition of bisecting N-acetylglucosamine to CDH1/E-cadherin modulates CDH1 cell membrane location. Inhibits NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc- formation which modulates sialylation levels and plays a role in cell migration regulation. In brain, addition of bisecting N-acetylglucosamine to BACE1 blocks its lysosomal targeting in response to oxidative stress and further degradation which increases its location to early endosome and the APP cleavage.
Gene References into Functions
  1. Novel insights into the epigenetic regulation of MGAT3/bisecting GlcNAc and demonstrate the importance of N-glycosylation in cancer progression. PMID: 27429195
  2. Data suggest that GNT-III expression regulates levels/activation of the heavily glycosylated Notch receptor involved in normal and malignant cell development; suppression of GNT-III in epithelial ovarian carcinoma cell lines results in down-regulation of Notch signaling that is more potent than pharmacologic blockage of Notch activation. PMID: 28842505
  3. MGAT3 expressed in cells stimulates lipid droplet growth. These findings provide additional evidence that MGAT3 likely functions as a triacylglycerol synthase in cells. PMID: 27184406
  4. Core-fucosylated tetra-antennary structures were decreased in quantity likely as a result of hypomethylated MGAT3 gene promoter followed by increased expression of this gene PMID: 27073020
  5. High expression of alpha2,6-sialylation on the cell surface could affect the anti-migratory role of GnT-III, which provides an insight into the mechanistic roles of GnT-III in tumor metastasis. PMID: 26801611
  6. Mgat3 plays an important role in early spontaneous miscarriage in humans. PMID: 26109616
  7. MGAT3 protein and gene expression in in uveal and cutaneous melanoma cells PMID: 26098720
  8. HS5 cells had significantly enhanced levels of bisecting N-glycans (catalyzed by MGAT3 whereas HS27a cells had enhanced levels of Galbeta1,4GlcNAc. PMID: 25936519
  9. GnT-III determines E-cadherin-mediated tumor suppression, and GnT-V regulates E-cadherin-mediated tumor invasion. PMID: 23671930
  10. Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor beta1 (TGF-beta1) in epithelial cell lines PMID: 22451656
  11. MGAT3 mRNA biomarker may characterize subgroups of Alzheimer's disease patients with different disease progression. PMID: 21368380
  12. the modulation of glycosyltransferases MGAT3 and MGAT5 by synthetic N-acetyl-D-glucosamine-calix[4]arene correlated with the improvement of NK cell effector functions and the augmentation of tumor cells sensitivity to NK cell-mediated cytotoxicity. PMID: 20089585
  13. upregulation of GnT-III in AD brains may represent an adaptive response to protect them from additional beta-amyloid production PMID: 19776078
  14. down-regulation of hydrogen peroxide-induced PKC delta activation in cells transfected with this enzyme PMID: 12427758
  15. MGAT3 and MGAT5 competitively modified E-cadherin N-glycans. PMID: 19403558

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Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Protein Families
Glycosyltransferase 17 family
Database Links

HGNC: 7046

OMIM: 604621

KEGG: hsa:4248

STRING: 9606.ENSP00000345270

UniGene: Hs.276808

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