MIB2 Antibody, Biotin conjugated

Datasheet
Code CSB-PA839291LD01HU
Size US$299
Uniprot No. Q96AX9
Protocols ELISA Protocol
Immunogen Recombinant Human E3 ubiquitin-protein ligase MIB2 protein (1-128AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Form Liquid
Conjugate Biotin
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias E3 ubiquitin-protein ligase MIB2 (EC 2.3.2.27) (Mind bomb homolog 2) (Novel zinc finger protein) (Novelzin) (Putative NF-kappa-B-activating protein 002N) (RING-type E3 ubiquitin transferase MIB2) (Skeletrophin) (Zinc finger ZZ type with ankyrin repeat domain protein 1), MIB2, SKD ZZANK1
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names MIB2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Subcellular Location Cytoplasm, Endosome
Tissue Specificity Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.
Database Links

HGNC: 30577

OMIM: 611141

KEGG: hsa:142678

STRING: 9606.ENSP00000426103

UniGene: Hs.135805

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