MICU2 Antibody, FITC conjugated

Code CSB-PA818265LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MICU2 Polyclonal antibody
Uniprot No.
Target Names
MICU2
Alternative Names
1110008L20Rik antibody; EF hand domain containing family member A1 antibody; EF hand domain family A1 antibody; EF hand domain family member A1 antibody; EF-hand domain-containing family member A1 antibody; EFHA1 antibody; EFHA1 EF hand domain family member A1 antibody; EFHA1_HUMAN antibody; FLJ25016 antibody; FLJ34588 antibody; Smhs2 homolog antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Calcium uptake protein 2, mitochondrial protein (26-247AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering.
Gene References into Functions
  1. MICU2 restricts spatial crosstalk between InsP3R and MCU channels by regulating threshold and gain of MICU1-mediated inhibition and activation of MCU. PMID: 29241542
  2. MICU2 expression in the heart tissues from patients with ventricular hypertrophy. PMID: 29073106
  3. study concludes that cooperative, high-affinity interaction of the MICU1-MICU2 complex with Ca(2+) serves as an on-off switch, leading to a tightly controlled channel, capable of responding directly to cytosolic Ca(2+) signals PMID: 28615291
  4. This is the first demonstration of MICU2 deficiency in humans, which we suggest causes a distinct neurodevelopmental phenotype secondary to impaired mitochondrial calcium uniporter-mediated regulation of intracellular calcium homeostasis. PMID: 29053821
  5. Expression of MICU2 mutants lacking functional Ca2+-binding sites leads to a striking loss of Ca2+ uptake in HEK293 cells. PMID: 24503055
  6. MICU1 and MICU2 have roles in tuning the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity PMID: 24560927
  7. The results identify MICU2 as a new component of the uniporter complex that may contribute to the tissue-specific regulation of this channel. PMID: 23409044
  8. regulation of MCU-mediated mitochondrial calcium handling PMID: 23409044
  9. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624
  10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614

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Subcellular Location
Mitochondrion intermembrane space.
Protein Families
MICU1 family, MICU2 subfamily
Database Links

HGNC: 31830

OMIM: 610632

KEGG: hsa:221154

STRING: 9606.ENSP00000371811

UniGene: Hs.412103

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