MIEF1 Antibody

Code CSB-PA021827GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
MIEF1
Alternative Names
MIEF1 antibody; MID51 antibody; SMCR7L antibody; Mitochondrial dynamics protein MID51 antibody; Mitochondrial dynamics protein of 51 kDa antibody; Mitochondrial elongation factor 1 antibody; Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like antibody; SMCR7-like protein antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human SMCR7L
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.
Gene References into Functions
  1. MiD51 inhibits Drp1, whereas ADP promotes MiD51-mediated fission. [review] PMID: 27660309
  2. The results indicate that Drp1-dependent mitochondrial fission through MiD49/MiD51 regulates cristae remodeling during intrinsic apoptosis. PMID: 26903540
  3. The cytoplasmic domain of MiD51 was overexpressed, purified and crystallized. PMID: 24817717
  4. MIEF1 and MIEF2 are differentially expressed in human tissues during development PMID: 23880462
  5. MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and suggest that they provide specificity to the division of mitochondria. PMID: 23921378
  6. we find that either MiD49 or MiD51 can mediate Drp1 recruitment and mitochondrial fission in the absence of Fis1 and Mff PMID: 23283981
  7. elevated MIEF1 levels induce mitochondrial fusion; depletion of MIEF1 causes mitochondrial fragmentation; MIEF1 interacts with and recruits Drp1 to mitochondria but inhibits Drp1 activity, executing a negative effect on mitochondrial fission PMID: 21701560
  8. MiD49/51 are new mediators of mitochondrial division affecting Drp1 action at mitochondria. PMID: 21508961
  9. Mitochondrial outer membrane protein that recruits fission mediator Drp1 to the mitochondrial surface. PMID: 21508961

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Subcellular Location
Mitochondrion outer membrane; Single-pass membrane protein.
Protein Families
SMCR7 family
Tissue Specificity
Expression is relatively high in heart, skeletal muscle, pancreas and kidney.
Database Links

HGNC: 25979

OMIM: 615497

KEGG: hsa:54471

STRING: 9606.ENSP00000327124

UniGene: Hs.728085

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