MIOS Antibody, HRP conjugated

Datasheet
Code CSB-PA865167LB01HU
Size US$299
Uniprot No. Q9NXC5
Protocols ELISA Protocol
Immunogen Recombinant Human GATOR complex protein MIOS protein (1-237AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210).
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias GATOR complex protein MIOS (Missing oocyte meiosis regulator homolog), MIOS
Immunogen Species Homo sapiens (Human)
Research Area Cell Biology
Target Names MIOS
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex
Subcellular Location Lysosome membrane
Protein Families WD repeat mio family
Database Links

HGNC: 21905

OMIM: 615359

KEGG: hsa:54468

STRING: 9606.ENSP00000339881

UniGene: Hs.520215

Pathway mTOR signaling pathway

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